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Diabetic macular edema (DME) remains an important cause of visual loss in patients with diabetes mellitus. Although photocoagulation and intensive control of systemic metabolic factors have been reported to achieve improved outcomes in large randomized clinical trials (RCTs), some patients with DME continue to lose vision despite treatment. Pharmacotherapies for DME include locally and systemically administered agents. We review several agents that have been studied for the treatment of DME.
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http://dx.doi.org/10.1155/2012/548732 | DOI Listing |
Ophthalmol Ther
March 2025
Department of Endocrinology and Metabolism, AIIMS, New Delhi, India.
Introduction: While many deep learning systems (DLSs) for diabetic retinopathy (DR) have been developed and validated on cohorts with an average age of 50s or older, fewer studies have examined younger individuals. This study aimed to understand DLS performance for younger individuals, who tend to display anatomic differences, such as prominent retinal sheen. This sheen can be mistaken for exudates or cotton wool spots, and potentially confound DLSs.
View Article and Find Full Text PDFInt Ophthalmol
March 2025
Ophthalmology Department, Faculty of Medicine, Niğde Ömer Halisdemir University, Bor Street, 51240, Niğde, Turkey.
Purpose: The aim of this study is to assess the choroidal features in patients diagnosed with non-advanced age-related macular degeneration (AMD) using Swept-source Optical Coherence Tomography (SS-OCT) and compare the findings of those with subretinal drusenoid deposits (SDD) and those with large drusen.
Methods: Individuals aged 50 years and above, presenting with either SDD or large drusen alongside non-advanced AMD, underwent a thorough ophthalmic assessment. OCT scans were acquired using SS-OCT.
Med Phys
March 2025
The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Background: Radiomics-based characterization of fluid and retinal tissue compartments of spectral-domain optical coherence tomography (SD-OCT) scans has shown promise to predict anti-VEGF therapy treatment response in diabetic macular edema (DME). Radiomics features are sensitive to different image acquisition parameters of OCT scanners such as axial resolution, A-scan rate, and voxel size; consequently, the predictive capability of the radiomics features might be impacted by inter-site and inter-scanner variations.
Purpose: The main objective of this study was (1) to develop a more generalized classifier by identifying the OCT-derived texture-based radiomics features that are both stable (across multiple scanners) as well as discriminative of therapeutic response in DME and (2) to identify the relative stability of individual radiomic features that are associated with specific spatial compartments (e/g.
Ophthalmic Surg Lasers Imaging Retina
March 2025
Background And Objective: While anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized treatment for diabetic macular edema, many patients still manifest refractory disease. This study evaluated rates of diabetic macular edema (DME) refractory to intravitreal bevacizumab in a diverse real-world setting, with the aim of studying demographic and optical coherence tomography (OCT)-based morphological factors associated with refractory disease.
Patients And Methods: This was a retrospective cohort study of patients receiving treatment.
Pathological ocular neovascularization, a characteristic feature of proliferative ocular diseases, is a primary contributor to global vision impairment. The dynamics of tubulin are crucial in maintaining ocular homeostasis, closely linked to cellular proliferation and angiogenesis. Elucidating the molecular mechanisms driving this process is vital for formulating effective therapeutic strategies.
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