Severely stenosed radiation-induced benign strictures around the level of cricopharyngeus post-radical chemoradiation for head and neck or upper esophageal cancers pose significant management problems. We report our technique of bidirectional assessment and dilatation of pharyngoesophageal strictures in patients with an in situ percutaneous endoscopic gastrostomy (PEG) tube. The upper gastrointestinal surgeon approached the area of stenosis in a retrograde manner through the PEG tube to guide the otolaryngeal surgeon who performed anterograde dilatation via a rigid laryngoscope. Between 2005 and 2009, bidirectional esophageal dilatation was performed on 5 patients at our institution. Video fluoroscopy confirmed improved patency of stenosed esophagus in all cases and good improvement in swallowing ability in 4 patients. The ability to accurately assess pharyngoesophageal strictures using bidirectional visualization and transillumination is the key modification of our technique. We suggest using bidirectional esophageal dilatation on difficult cases with severe pharyngoesophageal stenoses although extreme care is required.
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http://dx.doi.org/10.1002/hed.22993 | DOI Listing |
Front Endocrinol (Lausanne)
November 2024
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
BMC Cancer
November 2024
Academy of Zhongjing, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, China.
Background And Objectives: Currently, research on the role of B cells in esophageal cancer (EC) is limited, and existing studies on their impact are controversial. Therefore, this study was conducted to elucidate the complex causal relationship between B cells and EC, expand the understanding of esophageal cancer immunology.
Methods: Bidirectional two-sample Mendelian randomization (MR) was performed to assess the causal relationships between 190 B cell phenotypes and EC.
Front Med (Lausanne)
October 2024
Department of Gynecology and Obstetrics, West China Second Hospital, University of Sichuan, Chengdu, China.
Observational studies have reported an association between gastroesophageal reflux disease (GERD) and endometriosis. We conducted a two-sample and bidirectional Mendelian randomization analysis to determine whether those associations are causal. Two-sample and bidirectional MR analyses were performed using summary statistics from the European Individual Genome-Wide Association Study (GWAS).
View Article and Find Full Text PDFMed Biol Eng Comput
October 2024
Department of Biotechnology, Delhi Technological University (DTU), Delhi, 110042, India.
Front Endocrinol (Lausanne)
October 2024
Department of Cardiovascular Surgery, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Background: Emerging observational studies indicated an association between hyperthyroidism and gastrointestinal disorders. However, it remains unclear whether this association is causal, particularly in the case of gastroesophageal reflux (GERD) and esophageal cancer.
Methods: To assess the potential causal relationship between hyperthyroidism and GERD or esophageal cancer, we conducted a bidirectional 2-sample Mendelian randomization study.
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