Background: CD44 is a transmembrane receptor found on many different benign and malignant cells. Hyaluronan (HA), a major component of the extracellular matrix, is the primary ligand for CD44 receptors. In cancer cells, HA interaction with CD44 promotes multiple signaling pathways that influence tumor cell progression behaviors in a variety of solid tumors. Increasing evidence indicates that HA and CD44 signaling play an important role in oral cavity squamous cell carcinoma progression. HA is primarily synthesized by hyaluronan synthases, and the current study investigated the role of hyaluronan synthase 2 (HAS 2) in oral cavity carcinoma progression behaviors.
Methods: Analysis of HAS 2 mRNA and protein expression, HA production, and HAS 2-mediated tumor cell proliferation and migration behaviors with and without HAS 2 suppression were carried out on 2 established oral cavity cancer cell lines. Immunohistochemical analysis of HAS 2 and CD44 expression in oral cavity carcinoma tumor specimens was performed.
Results: HAS 2 was expressed in the 2 oral cancer cell lines, HSC-3 and SCC-4. Suppression of HAS 2 expression resulted in CD44-dependent decreased tumor cell migration, decreased tumor cell growth, and increased cisplatin sensitivity, suggesting the importance of tumor cell HA production to promote in vitro tumor progression behaviors in oral cancer cells. Increased HAS 2 expression in oral cavity carcinoma clinical specimens was associated with poor clinicopathologic characteristics and worse disease-free survival.
Conclusions: HAS 2 may be a potential therapeutic target for the treatment of oral cavity cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.22991 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tribbles pseudokinase 3 drives cancer stemness in oral squamous cell carcinoma cells by supporting the expression levels of SOX2 and EGFR.
Int J Mol Med
March 2025
Department of Biomedical Sciences, Chung Shan Medical University, Taichung 402306, Taiwan, R.O.C.
Oral squamous cell carcinoma (OSCC) is a type of head and neck cancer (HNC) with a high recurrence rate, which has been reported to be associated with the presence of cancer stem cells (CSCs). Tribbles pseudokinase 3 (TRIB3) is involved in intracellular signaling and the aim of the present study was to investigate the role of TRIB3 in the maintenance of CSCs. Analysis of The Cancer Genome Atlas database samples demonstrated a positive correlation between TRIB3 expression levels and shorter overall survival rates in patients with HNC.
View Article and Find Full Text PDFHuman-Inspired Control of a Whip: Preparatory Movements Improve Hitting a Target.
Proc IEEE RAS EMBS Int Conf Biomed Robot Biomechatron
September 2024
Department of Biology, Northeastern University, Boston, MA, USA.
Manipulating flexible and underactuated objects, such as a whip, remains a significant challenge in robotics. Remarkably, humans can skillfully manipulate such objects to achieve tasks, ranging from hitting distant targets to extinguishing a cigarette's in someone's mouth with the tip of a whip. This study explored this problem by constructing and modeling a 25-degree-of-freedom whip.
View Article and Find Full Text PDFTraumatic Neuroma as a Rare Complication of "Vel" Piercing.
Cureus
December 2024
Oral Pathology and Microbiology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Body piercing has become popular among people of all ages, inspired by religious convictions, personal aesthetics, and cultural influences. Piercings in the oral cavity frequently involve the lip, buccal mucosa, frenulum, and tongue with needles, hooks, and rings. However, these piercings might cause long-term problems to both the hard and soft tissues of the mouth.
View Article and Find Full Text PDFA Rare Case of Congenital Buccal Lipoblastoma in a Term Neonate.
Cureus
December 2024
Pediatrics/Neonatology, University of Arkansas for Medical Sciences, Little Rock, USA.
A lipoblastoma is a benign tumor of adipocytes originating from embryonic white fat and occurs in the pediatric population. Congenital lipoblastomas, however, are rare, and the incidence of these tumors in neonates is unknown. Due to their rare presentation, congenital oral lipoblastomas can, firstly, pose diagnostic challenges for the pediatrician and must be differentiated from the more commonly seen oral lesions in the newborn and other rare malignant growths.
View Article and Find Full Text PDFPharyngeal airway dimensions and adipose distribution in the minipig.
J Oral Biol Craniofac Res
December 2024
Department of Orthodontics, University of Washington, Seattle, USA.
Objective: To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model.
Materials And Methods: Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!