This study indicates the cellular and ultrastructural changes of the thigh muscle and sural nerve biopsies of a patient intoxicated as a result of isoniazid intake for tuberculosis treatment. The observation of the relative degradation of myelination and fibre type II groups was apparent. The regular concentric layers of the myelin sheath were destroyed. There was a consistent increase in irregular vacuolization and membranous structures in the axon and the cytoplasm of the Schwan cells. It is concluded that poisoning cannot be attributed solely to the axonal degradation but also to the direct toxic effect of the drug.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Endoscopic Flexor Hallucis Longus Tendon Transfer for the Treatment of Chronic Achilles Tendon Defects.
JBJS Essent Surg Tech
January 2025
The Ohio State University College of Medicine, Columbus, Ohio.
Background: An all-inside endoscopic flexor hallucis longus (FHL) tendon transfer is indicated for the treatment of chronic, full-thickness Achilles tendon defects. The aim of this procedure is to restore function of the gastrocnemius-soleus complex while avoiding the wound complications associated with open procedures.
Description: This procedure can be performed through 2 endoscopic portals, a posteromedial portal (the working portal) and a posterolateral portal (the visualization portal).
Middle and Long Latency Cutaneous Reflexes During the Stance Phase of Gait in Individuals with and Without Chronic Ankle Instability.
Brain Sci
December 2024
Department of Kinesiology, Indiana University, 1025 E 7th St, Bloomington, IN 47405, USA.
Background/objectives: Lower limb cutaneous reflex amplitudes can modulate across gait, which helps humans adjust rhythmic motor outputs to maintain balance in an ever-changing environment. Preliminary evidence suggests people who suffer from repetitive ankle sprains and residual feelings of giving way demonstrate altered cutaneous reflex patterns in the gastrocnemius. However, before cutaneous reflex assessment can be implemented as a clinical outcome measure, there is a need to substantiate these early findings by measuring reflex amplitudes across longer latency periods and exploring the variability of reflexes within each subject.
View Article and Find Full Text PDFThe plantaris muscle is spindle-shaped in the posterior compartment of the leg. It is distinguished for its small muscle belly and an exceptionally long tendon. It presents with great variability in its origin and insertion when present.
View Article and Find Full Text PDFCase report: Chronic inflammatory demyelinating polyradiculoneuropathy with severe central nervous system demyelination: a clinicopathological study.
Front Immunol
December 2024
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disease that mainly affects the peripheral nerves and nerve roots and typically presents with distal dominant motor and sensory disturbances as clinical symptoms. Central nervous system (CNS) demyelination with inflammation occurs infrequently in patients with CIDP. Here, we present a unique autopsy report of CIDP causing severe demyelination along the entire spinal cord.
View Article and Find Full Text PDFValidation of the Histamine- and Heat-Induced Axon-Reflex Flare Response in a Nonselected Population of People With Type 1 Diabetes.
Muscle Nerve
February 2025
Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
Introduction/aims: Diabetic peripheral neuropathy affects small nerve fibers early, but adequate evaluation has proven difficult. One method for functional assessment of small nerve fiber function is the axon-reflex flare (ARF) response. This study aimed to 1) validate the histamine-induced ARF response in a nonselected population with diabetes, 2) compare the response to that induced by local heating, and 3) compare both methods to an established method (quantitative sensory testing) in a nonselected population with diabetes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!