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Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry.
Anal Chem
March 2010
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30332, USA.
Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human immunodeficiency virus type 1 (HIV-1). NRTI-triphosphates (NRTI-TP) compete with endogenous 2'-deoxyribonucleosides-5'-triphosphates (dNTP) for incorporation by the HIV-1 reverse transcriptase (RT). Thus, a highly sensitive analytical methodology capable of quantifying at the low femtomoles/10(6) cells level was necessary to understand the intracellular metabolism and antiviral activity of NRTIs in human peripheral blood mononuclear (PBM) cells and in macrophages.
View Article and Find Full Text PDFThe incidence and prevalence of HIV infection among childbearing women living in Edinburgh city, 1982-1995.
AIDS
May 1998
Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
Objective: To track the complete course of the HIV epidemic among women from the city of Edinburgh who delivered babies during 1982-1995.
Methods: The performance of the modified Serodia HIV test on dried blood spots from archived neonatal metabolic screening cards stored for up to 11 years was evaluated by testing 221 cards from neonates whose mothers' HIV infection status was already known (100 HIV-positive, 121 HIV-negative). Unlinked anonymous HIV testing of cards from neonates born during 1982-1989 was then performed and the resulting prevalence data were combined with existing data from 1990-1995.
AIDS surveillance: a direct assessment of under-reporting.
AIDS
December 1993
Department of Public Health, Brent and Harrow Health Authority, London, UK.
Objective: To assess directly the extent of under-reporting of AIDS cases to the National AIDS surveillance system.
Design: All AIDS cases diagnosed from 1 January 1982 to 1 August 1989 in Riverside Health Authority were identified from a local register of HIV infection and cross-checked against records of AIDS cases reported to the national AIDS surveillance system.
Setting: Riverside Health Authority, London, UK.
Mycobacterial disease and AIDS in New South Wales.
Med J Aust
July 1992
Epidemiology and Health Services Evaluation Branch, New South Wales Health Department, North Sydney.
Objective: To determine the coincidence of mycobacterial disease and acquired immunodeficiency syndrome (AIDS), and whether persons with mycobacterial disease and human immunodeficiency virus (HIV) infection differ from those with mycobacterial disease alone, by age, sex and country of birth.
Design: A descriptive study.
Participants: Persons on the NSW Tuberculosis Register in 1989 and those on the NSW AIDS database in 1982-1989.
Determinants of survival in adult Brazilian AIDS patients, 1982-1989. The Brazilian State AIDS Program Co-Ordinators.
AIDS
May 1992
National Foundation of Health, Ministry of Health, Brasilia, Brazil.
Objective: Little has been published about the length and determinants of survival for persons with AIDS in developing countries. This study examined the survival experience of Brazilian AIDS patients from 1982 to 1989.
Design: A retrospective cohort study involving record review of reported AIDS cases.
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