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[Clinical characteristics and prognosis of acute erythroleukemia in children].
Zhongguo Dang Dai Er Ke Za Zhi
January 2025
Department of Children's Hematology and Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Objectives: To investigate the clinical characteristics and prognosis of acute erythroleukemia (AEL) in children.
Methods: A retrospective analysis was conducted on the clinical data, treatment, and prognosis of 8 children with AEL treated at the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2023.
Results: Among the 7 patients with complete bone marrow morphological analysis, 4 exhibited trilineage dysplasia, with a 100% incidence of erythroid dysplasia (7/7), a 71% incidence of myeloid dysplasia (5/7), and a 57% incidence of megakaryocytic dysplasia (4/7).
Management of Mandibular Condylar Fractures: A Comparison of Closed versus Open Reduction.
J Coll Physicians Surg Pak
January 2025
Department of Oral and Maxillofacial Surgery, The Armed Forces Institute of Dentistry, Rawalpindi, Pakistan.
Objective: To compare the closed reduction approach with open reduction (transparotid approach) in the management of condylar fractures for parameters such as postoperative facial nerve injury, trismus, and malocclusion.
Study Design: An analytical comparative study. Place and Duration of the Study: Department of Oral and Maxillofacial Surgery, The Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from 10th January 2022 to 1st October 2023.
Integrins identified as potential prognostic markers in osteosarcoma through multi-omics and multi-dataset analysis.
NPJ Precis Oncol
January 2025
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, Guangxi, China.
Osteosarcoma represents 20% of primary malignant bone tumors globally. Assessing its prognosis is challenging due to the complex roles of integrins in tumor development and metastasis. This study utilized 209,268 osteosarcoma cells from the GEO database to identify integrin-associated genes using advanced analysis methods.
View Article and Find Full Text PDFComparative analysis of patient demographics and outcomes in teaching and non-teaching hospitals in Iran.
Hosp Pract (1995)
January 2025
Education Development Center, Iran University of Medical Sciences, Tehran, Iran.
Aims: This study investigates the differences in patient demographics and outcomes between teaching and non-teaching hospitals in Iran. By analyzing these differences, it aims to provide useful information for policymakers to optimize resource allocation, improve patient care, and balance educational and service delivery goals in teaching hospitals.
Materials And Methods: In this cross-sectional investigation, both teaching and non-teaching general hospitals were examined.
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca/calcineurin pathway.
Biochem Pharmacol
January 2025
Department of Pharmacology, Nanjing Medical University, Nanjing 211166, PR China. Electronic address:
We have previously demonstrated that DEC1 promotes osteoblast differentiation. This study aims to evaluate the impact of DEC1 knockout on osteopenic activities, such as osteoclast differentiation and the expression of bone-degrading genes. To gain mechanistic insights, we employed both in vivo and in vitro experiments, utilizing cellular and molecular approaches, including osteoclast differentiation assays and RNA-seq in combination with ChIP-seq.
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