A patient with neurological symptoms underwent CT scan that showed a sellar and suprasellar mass with bone erosions, involving especially the clivus and the right petrous apex. The first diagnostic hypothesis was chordoma in relation to the mass position. The MRI showed a solid well-enhancing mass; moreover another circumscribed lesion, with similar signal pattern, was found in the left mandibular condyle. the signal and the presence of another lesion did not agree with diagnosis of chordoma. FDG-PET/CT study showed multiple pathological uptakes suggesting a metastatic disease. A trans-sphenoidal excisional biopsy was performed and the histopathological analysis showed a population of cells consistent with a plasmacell tumor, confirmed by the presence of a monoclonal gammopathy on blood analysis. Our case suggests that FDG-PET/CT can modify the diagnostic and therapeutic procedures in myeloma, by evaluating the bone marrow involvement.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303275 | PMC |
| http://dx.doi.org/10.3941/jrcr.v3i11.170 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tumor cells ectopically expressing the membrane-bound form of IL-7 develop an antitumor immune response efficiently in a colon carcinoma model.
Mol Cells
December 2024
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea. Electronic address:
Article Synopsis
- Researchers have explored various cytokine approaches to trigger antitumor responses, but issues with effectiveness and side effects have limited their use.
- In this study, interleukin-7 was modified to exist as both a secretory form and a membrane-bound form fused with B7.1 on colon cancer cells, showing they could stimulate CD8 T cell activation and antitumor responses similarly in lab conditions.
- Notably, the membrane-bound IL-7/B7 form led to significantly lower tumor growth in mice and induced long-lasting immunity against tumor cells, indicating it may be a more effective strategy for improving cancer treatment.
Experimental study on mechanical response and crack evolution law of coal and sandstone under different stress environments.
PLoS One
November 2024
School of Mining Engineering, Anhui University of Science and Technology, Huainan, Anhui, China.
In order to study the mechanical response and crack evolution law of different lithologic rock bodies under different stress environments in deep stress mines, based on the deviator stress theory, the actual triaxial disturbance unloading rock test system was used to simulate the stress occurrence environment of the original rock. The mechanical characteristics of different σ2 coal rock masses were studied, and the crack evolution law of coal and sandstone under different stress environments was analyzed. The results show that the increase of σ2 inhibits the deformation in the σ2 direction of coal and sandstone, promotes the expansion and deformation in the σ3 direction, and enhances its peak strength and elastic modulus.
View Article and Find Full Text PDFCentrifugal test on the mechanical characteristics of existing prestressed anchor bolts in highway widening.
Sci Rep
October 2024
School of Urban and Rural Planning and Architectural Engineering, ShangLuo University, ShangLuo, P.R. China.
To study the stress characteristics of existing prestressed bolts and slope stability during secondary excavation in a slope reconstruction and expansion project, five slope centrifugal tests were conducted. Tests focused on prestressed bolt-reinforced bedding slope with anchoring angles of 10°, 20°, 30°, 45°, and 60° during the excavation phase. The test results showed that the horizontal displacement at slope top increased slightly during the excavation of rock and soil masses in the upper slope part, while during the excavation of slope foot, such displacement increased rapidly.
View Article and Find Full Text PDFDynamic behavior of fractured gabbro treated by high temperatures.
Heliyon
October 2024
College of Geology and Environment, Xi'an University of Science and Technology, Xi'an, Shaanxi, 710000, China.
Rock masses in deep engineering are often subjected to high geothermal effect, and blasting is a key technique for deep rock excavation. It is crucial to study the dynamic characteristics of fractured rock masses under high geothermal conditions and blasting excavation. This paper focuses on fractured gabbro, examining the effects of high temperatures on its surface chromaticity and mass.
View Article and Find Full Text PDFApproach to cardiac masses: Thinking inside and outside the box.
World J Clin Cases
October 2024
Chief of Arrhythmology Lab, Cardiology Unit, Ramazzini Hospital, Carpi 41012, Modena, Italy.
Article Synopsis
- The editorial discusses cardiac masses, which include a variety of lesions that can be neoplastic (tumors) or non-neoplastic, highlighting the rarity of primitive cardiac tumors compared to the more frequent metastases and pseudotumors.
- Effective diagnosis and treatment of cardiac masses present challenges, making multimodal imaging essential, with cardiac magnetic resonance (CMR) being the gold standard for non-invasive tissue characterization.
- While standard diagnostic flow charts are useful, the complex nature of cancer patients—especially those with rare conditions—requires a multidisciplinary approach and flexibility in thinking beyond traditional methods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!