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Degradation of fenamates.
Profiles Drug Subst Excip Relat Methodol
January 2025
Department of Pharmaceutical Chemistry, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
Fenamates are the most crucial non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain-related diseases. The clinically prescribed drugs of the fenamate group include mefenamic acid, tolfenamic acid, meclofenamic acid, flufenamic acid, and niflumic acid. Due to their widespread use, all these drugs are considered as the most common water and sewerage pollutants.
View Article and Find Full Text PDFEfficacy and Safety of Abhal (Juniperus communis L). on Pain intensity, Uterine Artery Doppler Flow, and Quality of Life in Primary Dysmenorrhea: A Double-Blind, Randomized Controlled Trial.
J Ethnopharmacol
January 2025
Department of Ilmul Saidla (Pharmacy), National Institute of Unani Medicine, Ministry of Ayush, GOI, Bengaluru, India. Electronic address:
Ethnopharmacology Relevance: Incorporating ancient wisdom from Unani Medicine, this study delves into the therapeutic efficacy of Juniperus communis L. in primary dysmenorrhea. By seamlessly merging traditional knowledge with modern scientific evaluation, this research illuminates Juniperus communis L.
View Article and Find Full Text PDFA novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method.
RSC Adv
January 2025
Department of Chemistry, School of Science, GITAM Deemed to be University Hyderabad-502329 India
The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of mefenamic acid-N-nitroso drug substance-related impurity-NDSRI (N-MFA) in mefenamic acid (MFA) tablet and pediatric suspension dosage forms. The acceptable intake of N-MFA is derived from the TD50 (Median Toxic Dose-50%) value of N-nitroso diphenylamine. The analytical separation was achieved for the UPLC method using an XBridge BEH Shield RP18 Column (150 × 3.
View Article and Find Full Text PDFManganese(II) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure and Biological Activity.
Int J Mol Sci
December 2024
Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.
Nine manganese(II) complexes with a series of non-steroidal anti-inflammatory drugs (namely sodium diclofenac, diflunisal, flufenamic acid, sodium meclofenamate, mefenamic acid, and tolfenamic acid) were prepared in the presence of diverse nitrogen donors, i.e., pyridine, 1,10-phenanthroline, 2,2'-bipyridine and neocuproine, as co-ligands and were characterized with spectroscopic techniques and single-crystal X-ray crystallography.
View Article and Find Full Text PDFPatterns of Opioid and NSAID Use in Saudi Arabia from 2010 to 2020.
J Psychoactive Drugs
January 2025
Department of Pharmaceutical Care, King Fahad Medical City, Riyadh, Saudi Arabia.
The use of analgesics has increased globally over the last three decades. Prescription drug abuse has increased significantly, and opioids have been identified as causing further harm to the world. This study explored the utilization and expenditure associated with opioids and non-steroidal anti-inflammatory drugs (NSAIDs) from 2010 to 2020 in Saudi Arabia.
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