Pulmonary arterial hypertension, a common complication in patients with congenital heart defects with left-to-right shunt who present late is one of the principal determinants of the clinical manifestations, the course and the feasibility of surgical repair. The objective is to study the pulmonary arterial pressures and the pulmonary histopathological changes in patients having congenital heart defects with left-to-right shunt. A total of 20 consecutive patients having congenital heart defects with left-to- right shunt who underwent surgical correction were studied. Intra-operative mean pulmonary arterial pressures were measured before and after surgical correction. Lung biopsy was taken to study the histopathological changes of lung parenchyma and vasculature. All patients, irrespective of age at the time of surgical repair and the type and size of the cardiac defect had raised mean pulmonary arterial pressures that were decreased significantly immediately after surgical correction. Pulmonary parenchymal changes and vascular changes were noted in 18 and 9 patients respectively. The pulmonary vascular changes were significantly correlated with the mean pulmonary arterial pressures. The pulmonary parenchymal changes though were a consistent finding; not significantly correlated with the mean pulmonary arterial pressures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077164 | PMC |
| http://dx.doi.org/10.1007/s12262-010-0184-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of pulmonary hypertension and associated factors among rheumatic heart disease patients in Ethiopia.
BMC Cardiovasc Disord
January 2025
Department of Internal Medicine, Collage of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia.
Background: In developing countries evidences regarding pulmonary hypertension (PH) in rheumatic heart disease (RHD) patients are lacking, despite being responsible for significant morbidity and mortality. As a result, identifying the factors that influence PH is crucial to improve the quality of care.
Objective: To determine prevalence of pulmonary hypertension and its associated factors among rheumatic heart disease patients at the public hospitals of Bahir Dar city, Ethiopia.
A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome.
Sci Rep
January 2025
Department of Pathology, Dokkyo Medical University School of Medicine and Graduate School of Medicine, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (FO) in patients with acute respiratory distress syndrome (ARDS). Atelectasis, which is commonly observed in ARDS, not only leads to hypoxemia but also contributes to lung injury through hypoxia-induced alveolar tissue inflammation. Therefore, it is possible that excessively low FO may enhance hypoxia-induced inflammation in atelectasis, and raising FO to an appropriate level may be a reasonable strategy for its mitigation.
View Article and Find Full Text PDFRare occurrence of upper-limb ischaemia necessitating transhumeral amputation following axillary arterial line placement.
BMJ Case Rep
January 2025
Department of Orthopaedic Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
Arterial cannulation, commonly performed in the radial artery, is a widely used method for continuous blood pressure monitoring. Occasionally, the axillary artery is used as an alternate site of cannulation. However, complications like occlusion can lead to adverse events and severe outcomes.
View Article and Find Full Text PDFCurrent Concepts in Fluid Resuscitation and Vasopressor Use in Cirrhosis.
Semin Liver Dis
January 2025
Hepatology, University of Pennsylvania, Philadelphia, United States.
Critically ill patients with cirrhosis and liver failure not uncommonly have hypotension due to multifactorial reasons, that include hyperdynamic state with increased cardiac index, low systemic vascular resistance due to portal hypertension, following the use of beta blocker or diuretic therapy, and severe sepsis. These changes are mediated by microvascular alterations in the liver, systemic inflammation, activation of renin angiotensin aldosterone system, and vasodilatation due to endothelial dysfunction. Hemodynamic assessment includes measuring inferior vena cava indices, cardiac output and systemic vascular resistance using point-of-care ultrasound (POCUS), in addition to arterial waveform analysis, or pulmonary artery pressures, and lactate clearance to guide fluid resuscitation.
View Article and Find Full Text PDFCausal associations between telomere length and pulmonary arterial hypertension: A two-sample Mendelian randomization study.
Medicine (Baltimore)
November 2024
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by elevated pulmonary artery pressure, leading to right heart failure, and mortality. The role of telomere length, a marker of biological aging, in PAH remains unclear. We utilized summary-level data from genome-wide association studies for various measures of telomere length and PAH.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!