AI Article Synopsis
- The study aimed to evaluate how ageing affects the accuracy of glycosylated hemoglobin A1C (A1C) in diagnosing diabetes mellitus in Southeast Asians.
- A total of 511 subjects ranging from 14 to 93 years old were tested using A1C and the oral glucose tolerance test (OGTT), with comparisons made across four age groups.
- Results showed that older adults (≥65 years) had significantly higher false-negative rates for A1C, indicating it is less reliable for diagnosing diabetes in this age group, making OGTT a better choice.
Article Abstract
Objective: To determine the effect of ageing on the performance of glycosylated haemoglobin A1C (A1C) for the diagnosis of diabetes mellitus (DM) in Southeast Asians.
Methods: A1C was measured in 511 subjects (mean age of 52.4 years; range 14-93) undergoing the 75-g oral glucose tolerance test (OGTT). Using receiver operating curve (ROC) analysis, the performance of A1C for the diagnosis of diabetes (using different standard criteria) was compared between 4 groups: <45 (n=156), 45-54 (n=132), 55-64 (n=122), ≥65 years (n=101).
Results: Subjects aged ≥65 years had the highest false-negative rates with fasting plasma glucose (60.8%) and A1C (35.1%), the smallest area under ROC curve (0.723, 95% CI 0.627-0.820), the lowest sensitivity (58.7%, 95% CI 50.4-65.7) and specificity (71.1%, 95% CI 57.3-82.6) of A1C 6.5%, compared to the younger age groups.
Conclusion: OGTT is preferable for diagnosis of DM in older Southeast Asian adults.
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| http://dx.doi.org/10.1016/j.jdiacomp.2012.02.007 | DOI Listing |
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