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Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches.
PLoS One
December 2024
School of Life Science and Technology, Institut Teknologi Bandung, Bandung, West Java, Indonesia.
Article Synopsis
- The primary challenge in chronic hepatitis B is the immune system's inability to eliminate the cccDNA associated with the virus.
- Researchers are working on a new therapeutic vaccine utilizing a multi-epitope approach based on HBc and HBx proteins to target various HBV genotypes.
- This vaccine candidate shows potential for strong immune responses, global effectiveness, and stability, indicating significant progress in combating chronic hepatitis B.
The westward spread dynamics of cholera from the eastern endemic Democratic Republic of the Congo.
Emerg Microbes Infect
December 2025
Department of Internal Medicine, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Plant-Made Vaccines Targeting Enteric Pathogens-Safe Alternatives for Vaccination in Developing Countries.
Biotechnol Bioeng
December 2024
Immunology & Vaccinology Group. Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR). Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, B.C.S., México.
Article Synopsis
- * Current vaccines for diseases like rotavirus and cholera have been effective, but many other vaccines are still in development and face obstacles such as distribution and high production costs.
- * Plant-made vaccines are a promising solution, as they can be produced more affordably and delivered orally, eliminating the need for cold storage, though challenges in production efficiency and immunogenicity must still be addressed.
Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication.
Nat Chem Biol
October 2024
Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- Cholera toxin (CT) causes cholera by binding to intestinal cells, and different types of fucosylated glycoconjugates are involved in this process.
- Knocking out the B3GNT5 gene reduces CT binding in Colo205 cells but makes them more sensitive to CT intoxication, while increasing B3GNT5 levels can protect against CT.
- Conversely, knocking out B3GALT5 increases production of certain glycoproteins that enhance CT binding and intoxication, highlighting the role of fucosylated glycoproteins as important receptors for CT.
Background: In 2019-2020, preventative Oral Cholera Vaccine campaigns were conducted in 24/32 non-contiguous health areas of Goma, DR Congo. In August 2022, we measured coverage and factors potentially influencing success of the delivery strategy.
Methods: We used random geo-sampled stratified cluster survey to estimate OCV coverage and assess population movement, diarrhea history, and reasons for non-vaccination.
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