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Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review.
BMC Pediatr
January 2025
Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, Sichuan Province, China.
Background: Current treatment of giant omphalocele in newborns is not standardized. The main treatments include one-time repair and staged surgery using synthetic and biologic mesh, or silos. However, surgery can lead to various postoperative complications.
View Article and Find Full Text PDFExtemporaneous Compounding of Medicated Ointments.
Int J Pharm Compd
December 2024
Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois.
Article Synopsis
- Topical preparations, especially in dermatology, account for a significant portion of compounded prescriptions and involve varied ointment bases with active ingredients often added in liquid forms.
- There are currently no established quantitative guidelines on how different ointment bases absorb water and alcohol, prompting a short experiment to measure their capacity for these solvents.
- The findings aim to help compounding pharmacists choose the most appropriate base based on the solvent requirements for effective topical medications, while also offering insights into compounding challenges related to these preparations.
Comparing the efficacy of Zinc Oxide versus Vaseline prophylactic dressings in preventing sacral pressure injuries in patients admitted to the intensive care unit.
Int Wound J
November 2024
Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Preventing pressure injuries is a primary objective for care and treatment teams in intensive care units (ICUs). Therefore, the current study aimed to compare the efficacy of Zinc Oxide and Vaseline prophylactic dressings in preventing sacral pressure injuries in patients admitted to the ICU. This clinical trial was conducted in the ICU in 2023.
View Article and Find Full Text PDFTowards the discovery of unrevealed flufenamic acid cocrystals via structural resemblance for enhanced topical drug delivery.
Int J Pharm
January 2025
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong. Electronic address:
Cocrystallization has emerged as a promising formulation strategy for modulating transdermal drug absorption by enhancing solubility and permeability. However, challenges related to cocrystal dissociation in the semi-solid state need to be addressed to mitigate regulatory concerns before the widespread implementation of topical cocrystal products in clinical practice. This study aimed to develop oil-based topical formulations incorporating cocrystals with distinct thermodynamic stabilities, followed by investigating the roles of different structurally similar coformers and oily vehicles on their physicochemical properties.
View Article and Find Full Text PDFExtended Chemical and Microbial Stability of Various Hormones in Phytobase and HRT Heavy Cream Bases.
Int J Pharm Compd
August 2024
Compounding Support Services, Fagron Academy, St. Paul, Minnesota, USA.
Article Synopsis
- The 2023 updates to USP chapter <800> and major revisions to USP <795> have made previous studies for extended beyond use dates (BUD) inadequate, prompting a need for new evidence in compounding.
- Researchers conducted stability indicating testing and antimicrobial effectiveness testing (AET) on 12 combinations of topical and transdermal hormone preparations using two cream vehicles, Phytobase™ and HRT Heavy™, resulting in a total of 24 tested formulas.
- The study evaluates the appropriateness of Phytobase™ and HRT Heavy™ for compounded hormone therapy (CHT) and examines their compatibility with various hormones like estriol, estradiol, testosterone, progesterone, and dehydroepiandroster
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