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Ibandronate and periprosthetic bone mass: new therapeutic approach in periprosthetic loosening prevention. | LitMetric

AI Article Synopsis

  • A prosthetic implant changes how loads are transmitted to the bone, leading to a remodeling process that can cause periprosthetic bone loss.
  • Research has explored using bisphosphonates, particularly ibandronate, to prevent this bone loss and improve implant stability after surgery.
  • Ibandronate, given both intravenously and orally at specific intervals, has been shown to reduce bone thinning in key areas around the implant, potentially enhancing its longevity and preventing complications like aseptic loosening.

Article Abstract

A prosthetic implant modifies the physiological transmission of loads to the bone, initiating a remodeling process.Studies of the mechanisms responsible for periprosthetic bone loss contributed to the definition of new pharmacological strategies that may prevent aseptic implant loosening. Bisphosphonates are a class of drugs useful to this purpose, and have been shown to be effective in reducing periprosthetic resorption during the first year after the implant. We aimed to assess the inhibitory effect on periprosthetic osteolysis of ibandronate, a highly potent aminobisphosphonate, administered orally and IV with an extended interval between doses and optimal treatment adherence. In view of the fact that periprosthetic remodeling takes place during the first 6-12 months after surgery and is ultimately responsible for prosthesis longevity, we may conclude that the administration of high dosage ibandronate postsurgery by IV bolus and subsequently as cyclic oral treatment reduced cortical osteopenia in the metaphyseal region, and in the calcar region of the proximal femur. This therapy might therefore be used as preventive measure against postsurgical osteopenia and probably also against aseptic loosening.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230924PMC

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