AI Article Synopsis
- The study examined the link between metabolic syndrome and the risk of developing type 2 diabetes in older adults (ages 64+) over a 9-year period.
- A total of 1,117 individuals without diabetes at the beginning of the study were followed, and 69 (6.2%) developed type 2 diabetes by the end of the study.
- The results showed that those with metabolic syndrome had a significantly higher chance of developing type 2 diabetes, especially influenced by factors like impaired fasting glucose and obesity, indicating the need for focused prevention efforts in this demographic.
Article Abstract
The aim was to analyse the relationship between metabolic syndrome and type 2 diabetes mellitus risk among the aged. This was a prospective population-based study, with a 9-year follow-up. All subjects of the municipality of Lieto in Finland aged ≥64 in 1998-1999 with no type 2 diabetes mellitus at baseline (n=1117) were included. Hazard ratios for incident type 2 diabetes mellitus predicted by metabolic syndrome (defined by modified International Diabetes Federation criteria) were estimated. During the 9-year follow-up, a total of 69 participants (6.2%) developed type 2 diabetes mellitus. After multivariable adjustment (age, gender, smoking, frequency of exercise, cardiovascular disease and low-density lipoprotein-cholesterol), type 2 diabetes mellitus (hazard ratio, 95% confidence interval) (3.15, 1.89-5.25, p < 0.001) was more common in subjects with metabolic syndrome compared to subjects without it. Evaluating metabolic syndrome components individually, impaired fasting glucose (5.09, 2.64-9.82, p < 0.001) and obesity (1.71, 1.05-2.97, p = 0.034) predicted a higher incidence of type 2 diabetes mellitus. Our findings suggest that metabolic syndrome predicts onset of type 2 diabetes mellitus even in late life. Impaired fasting glucose and obesity should be targets for primary prevention of diabetes among the aged with metabolic syndrome.
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| http://dx.doi.org/10.1177/1479164112442077 | DOI Listing |
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