The long-recognized connection between homocysteine and thrombosis is examined in this issue of Blood in a study conducted by Dayal and colleagues. The results challenge the proposed mechanisms by which disordered homocysteine metabolism triggers vascular disease.
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Hyperhomocysteinemia prevalence among patients with venous thromboembolism.
Future Sci OA
December 2024
Biochemistry Laboratory, Hedi Chaker University Hospital, Sfax, Tunisia.
Aims: The objectives of this study were to determine the plasma homocysteine (Hcy) levels and the prevalence of Hyperhomocysteinemia HHC) in a group of Tunisian patients with deep vein thrombosis (DVT) by comparing it with healthy controls.
Methods: it was an observational case-control study including patients hospitalized for the management of unprovoked DVT. For each subject, a routine biochemical assay was conducted, including plasma homocysteine measurement and determination of vitamin B12 and B9 levels, as these vitamins are essential for assessing hyperhomocysteinemia in DVT patients due to their role in regulating homocysteine.
Relationship between homocysteine, vitamin B9, vitamin B12 levels methylenetetrahydrofolate reductase (C677T, A1298C) polymorphisms, and cryptogenic stroke in Tunisian adults´ patients: a case-control study.
Pan Afr Med J
November 2024
Clinical Investigation Center, Habib Bourguiba University Hospital of Sfax, Sfax, Tunisia.
Introduction: the relationship between elevated plasma homocysteine (Hcy) and stroke has been established, but this association remains indistinct in cryptogenic stroke in adults. Our aim is to investigate the association between homocysteine, vitamins B9 and B12, and cryptogenic stroke. Furthermore, to determine the correlation between methylenetetrahydrofolate reductase (MTHFR) polymorphism and biochemical levels in plasma.
View Article and Find Full Text PDFRetinal vascular events and relationship to CANCER development.
Thromb Res
December 2024
Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain; Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, Spain. Electronic address:
Background: Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal venous thrombosis and their relationship with the development of cancer.
View Article and Find Full Text PDFThe effect of hereditary thrombophilia on recurrent pregnancy loss: a retrospective cohort study.
BMC Pregnancy Childbirth
November 2024
Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.
Objective: Thrombophilia screening has been performed in patients with conditions such as previous fetal death, (fetal growth restriction) FGR, preeclampsia, (hemolysis. elevated liver enzyme, low platelet count) HELLP Syndrome, previous abruptio placentae, previous thrombosis in pregnancy, and abnormal placental histology. The actual role of hereditary thrombophilia in recurrent pregnancy loss (RPL) is still debated.
View Article and Find Full Text PDFPredictive factors for multivessel disease in patients with acute coronary syndrome: analysis from the CCC-ACS project in China.
BMC Cardiovasc Disord
November 2024
National Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Northern Theater Command, 83 Wenhua Road, Shenhe District, Shenyang, Liaoning, 110016, China.
Background: Multivessel disease(MVD) is linked to a poorer prognosis, increased complications, longer hospital stays, and higher in-hospital mortality when compared to single-vessel disease(SVD).The purpose of this study is to explore the clinically relevant predictors of acute cornary syndrome (ACS) combined with MVD.
Methods: This multicenter retrospective study included 68,378 ACS patients from 240 hospitals.
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