AI Article Synopsis
- The study explores noncovalent interactions between nanodiamond carboxylic acids, sourced from different adamantane derivatives, and β- and γ-cyclodextrins.
- The solubility of nanodiamonds in water was enhanced by attaching an aromatic dicarboxylic acid, and the thermodynamic properties of these interactions were analyzed using isothermal titration calorimetry.
- Results showed that larger nanodiamonds have stronger binding affinities, with γ-cyclodextrin preferentially binding bulkier nanodiamonds, while a notable complexation constant was recorded for 9-triamantane carboxylic acid with γ-cyclodextrin.
Article Abstract
We report on the noncovalent interactions of nanodiamond carboxylic acids derived from adamantane, diamantane, and triamantane with β- and γ-cyclodextrins. The water solubility of the nanodiamonds was increased by attaching an aromatic dicarboxylic acid via peptide coupling. Isothermal titration calorimetry experiments were performed to determine the thermodynamic parameters (K(a), ΔH, ΔG and ΔS) for the host-guest inclusion. The stoichiometry of the complexes is invariably 1:1. It was found that K(a), ΔG and ΔH of inclusion increase for larger nanodiamonds. ΔS is generally positive, in particular for the largest nanodiamonds. β-Cyclodextrin binds all nanodiamonds, γ-cyclodextrin clearly prefers the most bulky nanodiamonds. The interaction of 9-triamantane carboxylic acid shows one of the strongest complexation constants towards γ-cyclodextrin ever reported, K(a) = 5.0 × 10(5) M(-1). In order to gain some insight into the possible structural basis of these inclusion complexes we performed density functional calculations at the B97-D3/def2-TZVPP level of theory.
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