AI Article Synopsis
- The study aimed to assess how mesenchymal stem cells (MSCs) from specific mice, combined with platelet-rich plasma (PRP), affect the healing of severe bone defects in other mice.
- The experimental setup involved creating a 6.0mm cranial defect in twenty-four adult mice, with one group receiving treatment (MSC + PRP) and the other serving as a control.
- Results showed that the treated group experienced improved angiogenesis and bone repair compared to the control, indicating that MSCs and PRP positively influence bone healing.
Article Abstract
Purpose: To evaluate the effects of mesenchymal stem cells (MSC) from eight mice C57BL/6 gfp(+) bone marrows expanded in cultures associated with platelets rich plasma (PRP) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice C57BL/6.
Methods: The animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. Control group did not receive treatment and the treated group received a MSC pellet containing 1.0 x 10(7) cells/mL associated with 50.0 µL of plasma gel containing 1.0 x 10(9) autologous platelets within the defect.
Results: In the treated group was observed process of angiogenesis and bone repair better than control group.
Conclusion: Mesenchymal stem cells derived from bone marrow of C57BL/6 gfp(+) mice associated with PRP gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.
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| http://dx.doi.org/10.1590/s0102-86502012000300001 | DOI Listing |
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