(99m)Tc-labeled amine thiophene ligand might be a potential candidate for brain imaging. The purpose was to investigate the uptake of a radiolabeled drug in the brain. In this study, a tetradentate amine-thiophene-dione ligand was synthesized by the reaction of thiophene-2-carboxaldehyde with ethane-1,2-diamine and reducing with NaBH(4). The ligand system was characterized by elemental analysis, FTIR and 1H NMR. Radiolabeling of the complex with (99m)Tc was performed by reducing with stannous ions. The radiochemical purity of the radiolabeled drug was determined by paper chromatography (PC) and instant thin layer chromatography (ITLC). Bioevaluation of the (99m)Tc complex was studied in rabbits. The yield of the final product was 4.42 g (60%) and the characterization data confirmed the synthesis of the final product. The efficacy of radiolabeling was >98%. A significant uptake was observed in the brain which retained significantly upto 4h. The data indicate that the proposed system may be suitable for brain imaging in future clinical applications.
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Sci Rep
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Unlabelled: Despite the fact that canagliflozin (Cana), a sodium-glucose cotransporter 2 inhibitor, is an anti-diabetic medication with additional effects on the kidney, there is limited experimental data to deliberate its hepato-reno-protective potentiality. Acetaminophen (APAP) overdose remains one of the prominent contributors to hepato-renal damage.
Aim: Our study assessed the novel effect of Cana against APAP-induced toxicities.
J Colloid Interface Sci
December 2024
College of Chemistry and Chemical Engineering, Taishan University, Taian 271000, China. Electronic address:
Donor-acceptor (D-A) conjugated polymers have been widely reported as promising photocatalysts for organic conversion. However, achieving excellent photocatalytic performance still relies on the rational design of molecular structures and the careful selection of appropriate building blocks. In this study, we designed two D-A type conjugated porous polymers (CPPs) using 2,7,12-tribromo-5,5,10,10,15,15-hexamethyl-10,15-dihydro-5H-diindeno[1,2-a:1',2'-c]fluorene (Tx) as the donor unit and two 1,3,5-triazine-based derivatives, namely 2,4,6-tri(thiophen-2-yl)-1,3,5-triazine (TTT) and 2,4,6-triphenyl-1,3,5-triazine (TPT), as the acceptor units.
View Article and Find Full Text PDFKhirurgiia (Mosk)
December 2024
Tsivyan Novosibirsk Research Institute of Traumatology and Orthopedics, Novosibirsk, Russia.
Unlabelled: The issue of the treatment of purulent-inflammatory conditions affecting the fingers is a significant one, given the high prevalence of such cases, with up to 1.5 million instances reported annually in our country. The results of surgical treatment are frequently unsatisfactory, particularly in regard to functional indices, even in cases of mild soft tissue injury.
View Article and Find Full Text PDFCNS Neurosci Ther
December 2024
Department of Urology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Aim: Serotonin-norepinephrine reuptake inhibitors (SNRIs) have been extensively utilized for the treatment of depression and anxiety disorders. Clinical trials and real-world data suggest that SNRIs may cause reproductive toxicity. To comprehensively assess this association, we conducted a pharmacovigilance study.
View Article and Find Full Text PDFJ Postgrad Med
October 2024
Department of Clinical Pharmacology and Therapeutics, NIMS, Hyderabad, Telangana, India.
Background: Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication in diabetic mellitus patients due to chronic hyperglycemia, resulting in platelet hyperactivity and dyslipidemia. Alpha-lipoic acid (ALA) is a potent antioxidant which has antiplatelet activity and lipid-modulating characteristics and plays a major role in the prevention of disease progression.
Aim: To evaluate the effect of ALA on inhibition of platelet aggregation and lipid profile.
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