Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10888705.2012.658335 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deletion Variant in Basenji Dogs with Fanconi Syndrome.
Genes (Basel)
November 2024
Canine Genetics Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Fanconi syndrome is a disorder of renal proximal tubule transport characterized by metabolic acidosis, amino aciduria, glucosuria, and phosphaturia. There are acquired and hereditary forms of this disorder. A late-onset form of Fanconi syndrome in Basenjis was first described in 1976 and is now recognized as an inherited disease in these dogs.
View Article and Find Full Text PDFGenomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs.
PLoS One
November 2024
Department of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea.
Article Synopsis
- The Korean Sapsaree dog is a culturally significant native breed, and this study aimed to enhance genetic improvement and conservation by evaluating breeding values for various traits.
- Researchers analyzed phenotypic data from 378 dogs and performed a genome-wide association study (GWAS) to determine genomic regions affecting traits like body height and hair length.
- Results identified several significant SNPs and candidate genes linked to these traits, suggesting that targeted genomic insights can help improve the breeding quality of the Sapsaree dog.
Phenotypic characterization and quality of life of Labradoodles with idiopathic epilepsy and epilepsy of unknown cause.
Front Vet Sci
October 2024
Expertise Centre of Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Article Synopsis
- Idiopathic epilepsy (IE) is a chronic neurological disorder affecting Labradoodles, with a specific focus on characterization including age of onset, seizure frequency, and impact on quality of life for both dog and owner.
- An online survey involving Labradoodle owners revealed that 33 out of 40 dogs either had IE or were suspected of having it, with an average age of onset at 2.3 years and an average seizure frequency of 5.4 seizures per year; stress was the most common trigger for seizures.
- Despite some dogs experiencing severe forms of epilepsy, such as cluster seizures and status epilepticus, a majority managed well with minimal treatment, reflecting high quality of life scores for both the dogs
Investigation of the association of the MLPH gene with seasonal canine flank alopecia in Rhodesian Ridgeback dogs.
Canine Med Genet
October 2024
Expertise Centre of Genetics, Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Article Synopsis
- Canine flank alopecia (CFA) is a recurring skin condition in dogs, particularly affecting breeds like the Rhodesian Ridgeback, and is characterized by hair loss and skin darkening without inflammation.
- A study analyzed 24 dogs with CFA and 12 healthy controls, finding evidence of genetic inheritance but no significant differences linked to the melanophylin (MLPH) gene.
- Though pedigree analysis suggested a genetic influence on CFA, the MLPH gene was not implicated, indicating the need for further research to understand the genetic basis of CFA in these dogs.
Intragenic duplication disrupting the reading frame of MFSD8 in Small Swiss Hounds with neuronal ceroid lipofuscinosis.
Anim Genet
December 2024
Vetsuisse Faculty, Institute of Genetics, University of Bern, Bern, Switzerland.
Article Synopsis
- * Affected dogs exhibited significant brain degeneration and the presence of harmful autofluorescent materials in their neurons, which contributed to a preliminary diagnosis of NCL.
- * Genetic analysis identified an 18,819 base pair duplication in the MFSD8 gene in both dogs, which is linked to NCL in humans and other mammals, confirming the diagnosis as NCL7 and enabling future genetic testing to prevent breeding carriers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!