Stream-loading information was compiled from federal, state, and local agencies, and selected universities as part of an effort to develop regional SPAtially Referenced Regressions On Watershed attributes (SPARROW) models to help describe the distribution, sources, and transport of nutrients in streams throughout much of the United States. After screening, 2,739 sites, sampled by 73 agencies, were identified as having suitable data for calculating long-term mean annual nutrient loads required for SPARROW model calibration. These sites had a wide range in nutrient concentrations, loads, and yields, and environmental characteristics in their basins. An analysis of the accuracy in load estimates relative to site attributes indicated that accuracy in loads improve with increases in the number of observations, the proportion of uncensored data, and the variability in flow on observation days, whereas accuracy declines with increases in the root mean square error of the water-quality model, the flow-bias ratio, the number of days between samples, the variability in daily streamflow for the prediction period, and if the load estimate has been detrended. Based on compiled data, all areas of the country had recent declines in the number of sites with sufficient water-quality data to compute accurate annual loads and support regional modeling analyses. These declines were caused by decreases in the number of sites being sampled and data not being entered in readily accessible databases.
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http://dx.doi.org/10.1111/j.1752-1688.2011.00575.x | DOI Listing |
Adv Sci (Weinh)
December 2024
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, 8093, Switzerland.
The translation of cell-derived extracellular vesicles (EVs) into biogenic gene delivery systems is limited by relatively inefficient loading strategies. In this work, the loading of various nucleic acids into small EVs via their spontaneous hybridization with preloaded non-lamellar liquid crystalline lipid nanoparticles (LCNPs), forming hybrid EVs (HEVs) is described. It is demonstrated that LCNPs undergo pH-dependent structural transitions from inverse hexagonal (H) phases at pH 5 to more disordered non-lamellar phases, possibly inverse micellar (L) or sponge (L) phases, at pH 7.
View Article and Find Full Text PDFJ Control Release
December 2024
Department of Traumatology and Orthopaedic Surgery, Huizhou Central People's Hospital, Huizhou 516001, China; Hui Zhou-Hong Kong Bone Health Joint Research Center, Institute of Orthopaedics, Huizhou Central People's Hospital, Huizhou 516001, China. Electronic address:
Bacterial infections evoke considerable apprehension in orthopedics. Traditional antibiotic treatments exhibit cytotoxic effects and foster bacterial resistance, thereby presenting an ongoing and formidable obstacle in the realm of therapeutic interventions. Achieving bacterial eradication and osteogenesis are critical requirements for bone infection treatment.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
School of Materials Science & Engineering, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, PR China; Zotye Automobile Co., Ltd, Jinhua 321399, PR China. Electronic address:
The photocatalytic hydrogen (H) evolution reaction driven by solar energy is one of the most promising methods to alleviate energy and environmental problems. Regrettably, the rapid recombination of photogenerated electrons and hole pairs in semiconductor catalysts leads to low solar energy conversion efficiency. To address this problem, we chose the method of co-catalyst loading.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address:
Optimizing the design of nanoparticulate co-delivery systems of antigens and immunomodulators to induce antigen-specific immune tolerance effectively remains a challenge, constrained by low drug loading capacity and premature leakage of active ingredients. Here, we report a prodrug self-assembled nanoparticles (NPs) strategy to synergistically deliver antigen and rapamycin (RAPA) into antigen-presenting cells (APCs) by simply conjugating rapamycin with an aliphatic chain. These prodrug NPs can be efficiently taken up by APCs and then release rapamycin through cleavage of the linker by intracellular esterase.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China. Electronic address:
With the unique photo-physical properties and strong bio-compatibility. Quantum dots (QDs) have sparked interest in biomedical fields such as imaging, biosensing and therapeutics. However, the low stability and insufficient tumor specificity have largely constrained their potential biomedical applications.
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