Cervical radiculopathy (CR), while less common than conditions with neck pain alone, can be a significant cause of neck pain and disability; thus the determination of adequate treatment options for patients is essential. Currently, inadequate scientific literature restricts specific conservative management recommendations for CR. Despite a paucity of evidence for high-velocity low-amplitude (HVLA) spinal manipulation in the treatment for CR, this strategy has been frequently labeled as contraindicated. Scientific support for appropriate outcome measures for CR is equally deficient. While more scientific data is needed to draw firm conclusions, the present review suggests that spinal manipulation may be cautiously considered as a therapeutic option for patients suffering from CR. With respect to outcome measures, the Neck Disability Index appears well-suited for spinal manipulative treatment of CR.
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Background Low back pain (LBP) is a prevalent condition that significantly affects work productivity and quality of life. Despite advancements in treatment, LBP continues to pose a global health challenge, with increasing research on manipulative therapy as a non-invasive treatment option. This study aims to provide a comprehensive bibliometric analysis of global research trends in manipulative therapy for LBP.
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January 2025
Department of Bioengineering, Imperial College of London, London, UK.
Despite the advances in bionic reconstruction of missing limbs, the control of robotic limbs is still limited and, in most cases, not felt to be as natural by users. In this study, we introduce a control approach that combines robotic design based on postural synergies and neural decoding of synergistic behavior of spinal motoneurons. We developed a soft prosthetic hand with two degrees of actuation that realizes postures in a two-dimensional linear manifold generated by two postural synergies.
View Article and Find Full Text PDFInterv Pain Med
March 2025
Department of Pain Medicine, Mayo Clinic, Jacksonville, FL, USA.
Objectives: Patients suffering from chronic pain use online platforms, such as Reddit, to engage in personal exchanges while maintaining anonymity. Analysis of comments and questions posted on these online forums provide unique insight into conversations that patients may be having outside of the physician's office regarding pain-relief procedures, specifically radiofrequency ablation (RFA).
Materials And Methods: Using the Python Reddit Application Programming Interface Wrapper, we identified and screened Reddit users' posts.
Hum Mol Genet
January 2025
Centre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom.
Spinal Muscular Atrophy is an autosomal dominant disease caused by mutations and deletions within the SMN1 gene, with predominantly childhood onset. Although primarily a motor neuron disease, defects in non-neuronal tissues are described in both patients and mouse models. Here, we have undertaken a detailed study of the heart in the Smn2B/- mouse models of SMA, and reveal a thinning of the ventriclar walls as previously described in more severe mouse models of SMA.
View Article and Find Full Text PDFChiropr Man Therap
January 2025
Musculoskeletal Epidemiology Research Group, University of Zurich and Balgrist University Hospital, Zurich, Switzerland.
Background: Blinding is essential for mitigating biases in trials of low back pain (LBP). Our main objectives were to assess the feasibility of blinding: (1) participants randomly allocated to active or placebo spinal manual therapy (SMT), and (2) outcome assessors. We also explored blinding by levels of SMT lifetime experience and recent LBP, and factors contributing to beliefs about the assigned intervention.
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