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Review of Statistical Considerations and Data Imputation Methodologies in Psoriasis Clinical Trials.
J Clin Aesthet Dermatol
January 2024
Mr. Davidson is with Fallon Medica in Tinton Falls, New Jersey, and was an employee of Bristol Myers Squibb at the time of manuscript development.
Numerous clinical trials have established that various biologic and oral small-molecule therapies are efficacious in patients with psoriasis. However, as there are limited head-to-head trials, healthcare providers may compare results across multiple trials when providing treatment recommendations. Direct comparisons among agents are challenging because psoriasis trials differ in terms of study design, patient population, and data analysis methodologies.
View Article and Find Full Text PDFDevelopment and Optimization of a Nanoparticle-Based Imidacloprid Insecticide for Effective Control of .
J Arthropod Borne Dis
June 2024
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Background: The German cockroach () is a pest with a global distribution that has adapted to live in human environments. threatens human health by producing asthma-inducing allergens, carrying pathogenic/antibiotic-resistant microbes, and contributing to unhealthy indoor environments. Effective application of insecticides can play an important role in cockroach control programs.
View Article and Find Full Text PDF"Small is beautiful" - Examining reliable determination of low-abundant therapeutic antibody glycovariants.
J Pharm Anal
October 2024
Department of Biosciences and Medical Biology, Bioanalytical Research Labs, University of Salzburg, Salzburg, 5020, Austria.
Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy, and therefore, their reliable detection and quantification is essential. Our study introduces a multi-level quantification approach for glycosylation analysis in monoclonal antibodies (mAbs), focusing on minor abundant glycovariants. Mass spectrometric data is evaluated mainly employing open-source software tools.
View Article and Find Full Text PDFLiDAR point cloud denoising for individual tree extraction based on the Noise4Denoise.
Front Plant Sci
January 2025
Research Institute of Forest Policy and Information, Chinese Academy of Forestry, Beijing, China.
The processing of LiDAR point cloud data is of critical importance in the context of forest resource surveys, as well as representing a pivotal element in the realm of forest physiological and ecological studies.Nonetheless, conventional denoising algorithms frequently exhibit deficiencies with regard to adaptability and denoising efficacy, particularly when employed in relation to disparate datasets.To address these issues, this study introduces DEN4, an unsupervised, deep learning-based point cloud denoising algorithm designed to improve the accuracy of single tree segmentation in LiDAR point clouds.
View Article and Find Full Text PDFAdvances in Antidepressant Therapy: Comparing the Efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), and Novel Agents.
Cureus
December 2024
Family Medicine, Holy Family Hospital, Rawalpindi, PAK.
Introduction Depression is a prevalent and debilitating condition that often requires long-term medication management. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used but have limitations in efficacy and tolerability for some individuals. New antidepressant drugs targeting multiple pathways have shown potential in recent research.
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