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Metabolomic profile and its association with the diagnosis of prostate cancer: a systematic review.
J Cancer Res Clin Oncol
December 2024
Division of Urology/Urooncology, Department of Surgery, School of Medicine, Universidad del Valle, Calle 4 B # 36-00, Cali, Colombia.
Article Synopsis
- The study aimed to explore how a specific metabolomic profile can help diagnose localized prostate cancer by examining various biological samples.
- Researchers analyzed a total of 1248 studies, narrowing down to 14 case-control studies that primarily focused on serum metabolite analysis, revealing significant associations with certain metabolites.
- The findings indicated that disruptions in the metabolism of fatty acids, amino acids, nucleotides, and steroid hormones are linked to localized prostate cancer, with notable increases in amino acids like glutamate and aspartic acid, and decreases in glycine and serine.
Objective: To investigate whether the timing of bacillus Calmette-Guerin instillation (TTBCG), which plays a key role in treating non-muscle invasive bladder cancer (NMIBC), after transurethral resection of bladder tumor (TURBT) affects oncologic outcomes.
Methods: Patient data obtained from the Urologic Cancer Database-Bladder (UroCaD-B) of Turkish Uro-oncology Association (TUOA) were evaluated. Data from 292 patients from 12 centers with primary T1HG treated with TURBT and maintenance BCG between 2003 and 2023 were retrospectively analyzed.
Role of Microsurgery in Organ-Preserving Surgeries in Uro-oncology.
Indian J Surg Oncol
December 2024
Department of Plastic and Reconstructive Surgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.
Organ preservation surgery is the need of the hour in cancer management whenever it is feasible. Vascular continuity is a must for organ preservation. We found such same in this article.
View Article and Find Full Text PDFThe Value of Renal Clinical Nurse Specialists: Future Potential and Current Challenges in the United Kingdom.
Semin Oncol Nurs
December 2024
Lead Clinical Nurse Specialist Gestational Trophoblastic Disease and Rare Gynae Cancers, Imperial College.
Article Synopsis
- The renal clinical nurse specialist (CNS) serves as a vital support and information source for patients with kidney cancer, especially during advanced treatment stages.
- There are challenges in the UK, including a decreasing urology workforce and a recruitment crisis that leaves many new CNSs without necessary competencies.
- Improved kidney cancer treatments require dedicated CNSs to help manage patient care throughout the cancer journey, supported by educational initiatives like ACCEND and RCC4Nurses to enhance CNS skills and effectiveness.
Analysis of risk factors for cancer-specific survival in neoadjuvant chemotherapy nonresponsive disease of muscle-invasive bladder cancer: A multicentre study from the Turkish Urooncology Association Bladder Tumor study group.
Urol Oncol
January 2025
Department of Urology, Acibadem University, Istanbul, Turkey.
Article Synopsis
- The study aimed to evaluate factors impacting cancer-specific survival (CSS) in muscle-invasive bladder cancer (MIBC) patients who did not respond to neoadjuvant chemotherapy (NAC) before undergoing radical cystectomy (RC).
- Researchers examined various clinical and pathological characteristics, comparing NAC-responsive and NAC-non-responsive patients, focusing on data from 92 male-dominant participants averaging 61.5 years in age.
- Results indicated that while factors like a higher ECOG score and fewer NAC cycles correlated with non-responsiveness, the only significant prognostic factor for CSS in non-responsive patients was the presence of ypN+ status.
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