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Nontuberculous Mycobacterial Infective Endocarditis: A Systematic Review of Clinical Characteristics and Outcomes.
Open Forum Infect Dis
December 2024
Division of Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Background: Infective endocarditis (IE) due to nontuberculous mycobacteria (NTM) is a rare infection, and several outbreaks have been reported in the last 2 decades. However, the clinical spectrum is still poorly understood. This systematic review aimed to evaluate the clinical characteristics and outcomes in NTM IE.
View Article and Find Full Text PDFSystematic literature review of the diagnosis, prognosis, and treatment of peritoneal dialysis-related infection caused by nontuberculous mycobacteria.
BMC Nephrol
November 2024
Department of Nephrology, St. Luke's International Hospital, Tokyo, Japan.
Article Synopsis
- * A systematic review of 335 cases revealed that Mycobacterium abscessus was the most frequently identified pathogen, with many patients receiving treatment using multiple antibiotics.
- * Early diagnosis using acid-fast bacilli staining and culture is crucial, and catheter removal may be necessary for effective management of these NTM infections.
Clinical spectrum of extrapulmonary non-tuberculous mycobacterial disease in immunocompetent patients: a case series.
Germs
June 2024
MD, Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, 342005, India.
Article Synopsis
- * The case report outlines four instances of extrapulmonary NTM disease in immunocompetent patients, with varied clinical outcomes ranging from meningitis and brain abscesses to cervical lymphadenopathy, highlighting misdiagnoses with tuberculosis.
- * The findings emphasize the importance of awareness among clinicians regarding NTM disease, as early diagnosis and appropriate treatment are crucial for improving patient outcomes, especially for those with more severe infections.
Advances in antibacterial agents for .
RSC Med Chem
October 2024
Department of Pharmacy, Health Sciences Centre, Federal University of Santa Maria Santa Maria RS Brazil +55 (55) 3220 9372.
Article Synopsis
- The text discusses the rise of an emerging human pathogen, a type of nontuberculous mycobacterium (NTM), which has shown increased prevalence and antibiotic resistance, emphasizing the need for new drug development.
- It summarizes research over the past 20 years on various compounds that have antimycobacterial properties, focusing on promising synthetic drugs like macozinone and natural products like clostrubin and sansanmycin analogs.
- The review highlights specific mechanisms of action for some compounds, such as NITD-916 and TBAJ-5307, and explores the pathogenic mechanisms and potential therapeutic targets within this NTM.
Synthesis, Biological Evaluation, Molecular Docking Studies and ADMET Prediction of Oxindole-Based Hybrids for the Treatment of Tuberculosis.
Curr Comput Aided Drug Des
October 2024
Parul Institute of Pharmacy & Research, Parul University Department of Pharmacology Vadodara India.
Introduction: With a projected mortality toll of 1.4 million in 2019, tuberculosis (TB) continues to be a significant public health concern around the world. Studies of novel treatments are required due to decreased bioavailability, increased toxicity, increased side effects, and resistance of several first- and second-line TB therapies, including isoniazid and ethionamide.
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