Background: Humoral mediators of inflammation, in particular the complement system, have been described to play an important role in atherogenesis. Previously, we found a single-nucleotide polymorphism (SNP) in the complement 5 gene (C5 rs17611, A>G) independently associated with stroke. Up to now, the impact of C5 rs17611 on the progression of atherosclerosis and cardiovascular outcome in patients with asymptomatic atherosclerosis was unclear.
Materials And Methods: We investigated C5 rs17611 in a cohort of 1065 consecutive patients with asymptomatic carotid atherosclerosis. All patients were prospectively followed for the progression of carotid atherosclerosis and the development of a first major cardiovascular event (MACE), respectively.
Results: Three hundred and thirty-seven patients (31·6%) experienced a MACE during a median follow-up of 3·0 years. The homozygous GG genotype of the C5 rs17611 was significantly associated with adverse cardiovascular outcome (adjusted HR: 1·36 [95% CI, 1·07-1·73]; P = 0·01). After stratification for sex, C5 rs17611 CC was found to be an independent risk factor for MACE in men (HR 1·50 [95% CI, 1·12-1·83]). No association of C5 rs17611 with progression of carotid stenosis, observed in 93 (8·7%) patients, was detectable. Performance of ELISA indicated a significant association of the C5 rs17611 variant with C5a plasma levels.
Conclusion: The C5 rs17611 GG genotype is associated with increased C5a plasma levels and represents a risk factor for adverse cardiovascular outcome in male patients with carotid atherosclerosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2362.2012.02669.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Time Perception and Enjoyment of Professional Soccer Players in Different Training Sessions: Implications for Assessment of Session-RPE and Training Load.
J Strength Cond Res
December 2024
School of Psychology, Faculty of Life and Health Sciences, Ulster University, Coleraine, Northern Ireland.
Edwards, AM, Coleman, D, Fuller, J, Kesisoglou, A, and Menting, SGP. Time perception and enjoyment of professional soccer players in different training sessions: Implications for assessment of session-RPE and training load. J Strength Cond Res 38(12): e754-e760, 2024-The purpose of this study was to investigate whether the perception of time and enjoyment levels among professional soccer players varied according to the type of training undertaken and whether this influenced the training load (TL) assessment method of session-rating of perceived exertion (sRPE).
View Article and Find Full Text PDFAntiseizure Medications in Poststroke Seizures: A Systematic Review and Network Meta-Analysis.
Neurology
February 2025
Department of Neurology, Yale University School of Medicine, New Haven, CT.
Background And Objectives: The most effective antiseizure medications (ASMs) for poststroke seizures (PSSs) remain unclear. We aimed to determine outcomes associated with ASMs in people with PSS.
Methods: We systematically searched electronic databases for studies on patients with PSS on ASMs.
Annual Survey of State and Territorial Chronic Disease Prevention and Health Promotion Capacity and Organizational Development Needs-United States, 2023.
J Public Health Manag Pract
November 2024
Author Affiliations: National Association of Chronic Disease Directors, Decatur, Georgia (Dr Lankau, Mss Dudley, Miller, and Shields, Dr Alongi, Ms Macchi, and Dr Hohman); and Public Health Associate Program, Centers for Disease Control and Prevention, Atlanta, Georgia (Ms Chiang).
Objective: The National Association of Chronic Disease Directors (NACDD) is a nonprofit organization that supports state and territorial chronic disease prevention and health promotion efforts through capacity building and technical assistance. Each year, NACDD surveys health department leaders who oversee chronic disease prevention and health promotion (hereafter, Chronic Disease Directors). We have previously used the annual survey results to inform strategic planning and resource allocation but have not historically published key findings in the peer-reviewed literature.
View Article and Find Full Text PDFTime Perception and Enjoyment of Professional Soccer Players in Different Training Sessions: Implications for Assessment of Session-RPE and Training Load.
J Strength Cond Res
September 2024
School of Psychology, Faculty of Life and Health Sciences, Ulster University, Coleraine, Northern Ireland.
Edwards, AM, Coleman, D, Fuller, J, Kesisoglou, A, and Menting, SGP. Time perception and enjoyment of professional soccer players in different training sessions: Implications for assessment of session-RPE and training load. J Strength Cond Res XX(X): 000-000, 2024-The purpose of this study was to investigate whether the perception of time and enjoyment levels among professional soccer players varied according to the type of training undertaken and whether this influenced the training load (TL) assessment method of session-rating of perceived exertion (sRPE).
View Article and Find Full Text PDFDouble kissing crush versus culotte for bifurcation percutaneous coronary interventions: insights from the PROGRESS-BIFURCATION registry.
J Invasive Cardiol
January 2025
Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota. Email:
Background: Upfront 2-stent techniques are often used in bifurcation percutaneous coronary interventions (PCI), but there is controversy about optimal strategy selection.
Methods: The authors examined the clinical and angiographic characteristics and long-term outcomes of 232 bifurcation PCIs that were performed using the double kissing (DK) crush or culotte technique in 216 patients between 2014 and 2023 using data from the Prospective Global Registry for the Study of Bifurcation Lesion Interventions (NCT05100992). The inverse probability of treatment weighted (IPTW) Cox proportional hazards model was used to assess long-term outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!