AI Article Synopsis
- The study explored the effectiveness of silk peptide in treating atopic dermatitis using a mouse model, showing it can reduce symptoms by lowering serum IgE levels.
- Silk peptide treatment also influenced immune cell activity, boosting the production of IFN-γ (which helps fight inflammation) while reducing IL-4 (linked to allergic responses), leading to decreased IgE production.
- Analysis identified the active components of silk peptide as a mix of GAGA sequences, which help balance Th1 and Th2 immune responses, suggesting a potential therapeutic role for silk peptide in managing atopic dermatitis.
Article Abstract
The efficacy of silk peptide in treatment of atopic dermatitis was examined in a picryl chloride-induced atopic dermatitis model in NC/Nga mice. Silk peptide ameliorated the development of atopic dermatitis by lowering the serum IgE concentration. Treatment of cultured spleen cells with silk peptide reduced IgE production by enhancing the production of IFN-γ and reducing the level of IL-4. The functional peptides in the silk peptide were identified as mixture of GAGA sequences containing peptides by mass spectrometry and in vitro assay. Our findings indicate that silk peptide exerts an effect on atopic dermatitis by modulating the Th1/Th2 balance.
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| http://dx.doi.org/10.1271/bbb.110748 | DOI Listing |
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