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A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions.
Transl Res
April 2023
Laboratory of Vascular Pathobiology, Versiti Blood Center of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin; Department of Medicine, Medical Colleges of Wisconsin, Milwaukee, Wisconsin. Electronic address:
CD36 is a transmembrane glycoprotein receptor for oxidized low density lipoprotein (LDL) and other endogenous danger signals and promotes athero-thrombotic processes. CD36 has been shown to associate physically with other transmembrane proteins, including integrins, tetraspanins, and toll-like receptors, which modulate CD36-mediated cell signaling. The CD36 N-terminal transmembrane domain (nTMD) contains a GXXXG sequence motif that mediates protein-protein interactions in many membrane proteins.
View Article and Find Full Text PDFAutophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis.
Cell Death Differ
February 2022
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Mitochondria support multiple cell functions, but an accumulation of dysfunctional or excessive mitochondria is detrimental to cells. We previously demonstrated that a defect in the autophagic removal of mitochondria, termed mitophagy, leads to the acceleration of apoptosis induced by herpesvirus productive infection. However, the exact molecular mechanisms underlying activation of mitophagy and regulation of apoptosis remain poorly understood despite the identification of various mitophagy-associated proteins.
View Article and Find Full Text PDFConserved GxxxG and WN motifs of MIC13 are essential for bridging two MICOS subcomplexes.
Biochim Biophys Acta Biomembr
December 2021
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine-University Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Düsseldorf, Germany. Electronic address:
Mitochondrial ultrastructure is highly adaptable and undergoes dynamic changes upon physiological and energetic cues. MICOS (mitochondrial contact site and cristae organizing system), a large oligomeric protein complex, maintains mitochondrial ultrastructure as it is required for formation of crista junctions (CJs) and contact sites. MIC13 acts as a critical bridge between two MICOS subcomplexes.
View Article and Find Full Text PDFStructure-Function Analysis of Immune Receptor RLP23 with Its Ligand nlp20 and Coreceptors SOBIR1 and BAK1.
Mol Plant Microbe Interact
August 2019
1Eberhard-Karls-University Tübingen, Center of Plant Molecular Biology, Auf der Morgenstelle 32, D-72076 Tübingen, Germany.
Pattern-triggered immunity is an inherent feature of the plant immune system. Recognition of either microbe-derived surface structures (patterns) or of plant materials released due to the deleterious impact of microbial infection is brought about by plasma membrane pattern recognition receptors (PRRs). PRRs composed of leucine-rich repeat (LRR) ectodomains are thought to mediate sensing of proteinaceous patterns and to initiate signaling cascades culminating in the activation of generic plant defenses.
View Article and Find Full Text PDFRole of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase.
Elife
February 2017
BMC-Physiological Chemistry, LMU Munich, Martinsried, Germany.
The majority of mitochondrial proteins use N-terminal presequences for targeting to mitochondria and are translocated by the presequence translocase. During translocation, proteins, threaded through the channel in the inner membrane, are handed over to the import motor at the matrix face. Tim17 is an essential, membrane-embedded subunit of the translocase; however, its function is only poorly understood.
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