Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism.
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Article Synopsis
- Huntington's disease (HD) is a progressive brain disorder with no effective treatments, and the inflammasome NLRP3's role in HD is not well understood.
- This study tested the effects of Parthenolide (PTL), a natural compound that might inhibit NLRP3, on symptoms induced by 3-nitropropionic acid (3NP) in rats.
- Results showed that PTL improved behavioral and cognitive functions, protected neurons, and altered specific biochemical markers associated with neuroprotection in the striatum of the rats.
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