IncK plasmids encoding CTX-M-14 extended-spectrum β-lactamase (ESBL) and highly related to plasmid pCT were detected in 13 of 67 (19%) human clinical isolates of Escherichia coli with a group 9 CTX-M-type ESBL from the United Kingdom and in 2 quality assurance isolates. None of these E. coli strains was related to the cattle strain from which pCT was originally characterized.
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http://dx.doi.org/10.1128/AAC.00313-12 | DOI Listing |
Microbiology (Reading)
August 2024
Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Antibiotics (Basel)
April 2024
National Food Institute, Technical University of Denmark, 2800 Lyngby, Denmark.
carrying IncK- plasmids mediating resistance to extended-spectrum cephalosporins (ESC) has been frequently described in food-producing animals and in humans. This study aimed to characterize IncK--positive ESC-resistant isolates from poultry production systems in Denmark, Finland, and Germany, as well as from Danish human blood infections, and further compare their plasmids. Whole-genome sequencing (Illumina) of all isolates ( = 46) confirmed the presence of the gene.
View Article and Find Full Text PDFOpen Res Eur
October 2023
Wageningen Bioveterinary Research, Lelystd, 8221 RA, The Netherlands.
Antibiotics (Basel)
November 2023
National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
The emergence of extended-spectrum cephalosporin (ESC)-resistant is a global concern. This study aimed to assess the prevalence and transmission of ESC-resistant in the Danish broiler production system. Samples from two vertically integrated Production Systems (1 and 2) and two slaughterhouses (A and B) were analyzed (n = 943) for the occurrence of ESC-resistant from 2015 to 2018.
View Article and Find Full Text PDFMicrobiol Spectr
June 2023
Department of Microbiology, Faculty of Medicine, University Hospital in Pilsen, Charles University, Pilsen, Czech Republic.
Fosfomycin (FOS) has been recently reintroduced into clinical practice, but its effectiveness against multidrug-resistant (MDR) is reduced due to the emergence of FOS resistance. The copresence of carbapenemases and FOS resistance could drastically limit antibiotic treatment. The aims of this study were (i) to investigate fosfomycin susceptibility profiles among carbapenem-resistant (CRE) in the Czech Republic, (ii) to characterize the genetic environment of genes among the collection, and (iii) to evaluate the presence of amino acid mutations in proteins involved in FOS resistance mechanisms.
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