Purpose: Endoscopic staplers are the dominant tools to divide tubular structures in thoracoscopic lobectomy. However, passing these devices can be challenging because of limitations in their design.
Description: Two independent concepts were combined into one design aiming to overcome the limitation of passing the straight anvil of an endoscopic stapler through a tunnel typically created by a curved dissection instrument within the complex cluster of tubular structures that comprise the pulmonary hilum.
Evaluation: A library of 45 unedited advanced thoracoscopic lung resection videos containing a balance of all major anatomic resections (36 lobectomy and 9 pneumonectomy) spanning 2004 to 2011 were reviewed, and 220 hilar structure division times were measured along with the adjunctive techniques like catheter leaders or silicone slings. Prolonged passage times occurred throughout the series despite improved experience; however, early experience with 51 passes using the new design showed significant time savings (median 61 s versus 115 s, p = 0.005).
Conclusions: Curved tip anvils for endoscopic linear cutting staplers appear useful to speed thoracoscopic lung resections.
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http://dx.doi.org/10.1016/j.athoracsur.2011.11.030 | DOI Listing |
Comput Methods Programs Biomed
January 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing 100124, China. Electronic address:
Background And Objective: In clinical practice, valve-sparing aortic root replacement surgery primarily addresses left ventricular dysfunction in patients due to severe aortic regurgitation, but there is controversy regarding the choice of surgical technique. In order to investigate which type of valve-sparing aortic root replacement surgeries can achieve better blood flow conditions, this study examines the impact of changes in the geometric morphology of the aortic root on the hemodynamic environment through numerical simulation.
Methods: An idealized model of the aortic root was established based on data obtained from clinical measurements, including using the model of the aortic root without significant lesions as the control group (Model C), while using surgical models of leaflet reimplantation with tubular graft (Model T), leaflet reimplantation with Valsalva graft (Model V), and the Florida sleeve procedure (Model F) as the experimental groups.
bioRxiv
December 2024
Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.
Cannulae are tubular protein filaments that accumulate on the extracellular surface of the hyperthermophilic archaeon during cell division. Cannulae have been postulated to act as a primitive extracellular matrix through which cells could communicate or exchange material, although their native biological function remains obscure. Here, we report cryoEM structural analyses of cannulae and of protein assemblies derived from recombinant cannula-like proteins.
View Article and Find Full Text PDFbioRxiv
December 2024
Rutherford Appleton Laboratory, Research Complex at Harwell, Didcot, Oxfordshire, UK.
Conjugation, the major driver of the spread of antimicrobial resistance genes, relies on a conjugation pilus for DNA transfer. Conjugative pili, such as the F-pilus, are dynamic tubular structures, composed of a polymerized pilin, that mediate the initial donor-recipient interactions, a process known as mating pair formation (MPF). IncH are low-copy-number plasmids, traditionally considered broad host range, which are found in bacteria infecting both humans and animals.
View Article and Find Full Text PDFFood Chem
January 2025
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Wuhan 430070, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China. Electronic address:
Consumption of contaminated wines is a significant source of ochratoxin A (OTA) intake in humans, yet existing techniques for OTA removal are inadequate. This study constructs a TiO/SiO/g-CN catalyst (TiSiMs-TCN) with a tubular structure, capable of efficiently removing OTA from both simulated and real wines under visible light irradiation. The results of experiments, characterizations, and theoretical calculations demonstrate that the incorporation of silica enhances the adsorption capacity for OTA, and the tubular structure improves the catalyst's photoelectric properties.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Background: Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed by human chorionic gonadotropin (hCG) therapy; however, a portion of treated patients do not show a significant improvement in testis volume and vascularization after adjuvant therapy.
Methods: In this study, we generated an in vitro model to predict the patient response to hCG by cultivating and treating primary cells derived from five cryptorchid patients' biopsies of gubernaculum testis, the ligament that connects the testicle to the scrotum.
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