Background: Unilateral peripheral vestibular loss results in gait and balance impairment, dizziness and oscillopsia. Vestibular rehabilitation benefits patients but optimal treatment remains unknown. Virtual reality is an emerging tool in rehabilitation and provides opportunities to improve both outcomes and patient satisfaction with treatment. The Nintendo Wii Fit Plus® (NWFP) is a low cost virtual reality system that challenges balance and provides visual and auditory feedback. It may augment the motor learning that is required to improve balance and gait, but no trials to date have investigated efficacy.
Methods/design: In a single (assessor) blind, two centre randomised controlled superiority trial, 80 patients with unilateral peripheral vestibular loss will be randomised to either conventional or virtual reality based (NWFP) vestibular rehabilitation for 6 weeks. The primary outcome measure is gait speed (measured with three dimensional gait analysis). Secondary outcomes include computerised posturography, dynamic visual acuity, and validated questionnaires on dizziness, confidence and anxiety/depression. Outcome will be assessed post treatment (8 weeks) and at 6 months.
Discussion: Advances in the gaming industry have allowed mass production of highly sophisticated low cost virtual reality systems that incorporate technology previously not accessible to most therapists and patients. Importantly, they are not confined to rehabilitation departments, can be used at home and provide an accurate record of adherence to exercise. The benefits of providing augmented feedback, increasing intensity of exercise and accurately measuring adherence may improve conventional vestibular rehabilitation but efficacy must first be demonstrated.
Trial Registration: Clinical trials.gov identifier: NCT01442623.
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http://dx.doi.org/10.1186/1472-6815-12-3 | DOI Listing |
Chirurgie (Heidelb)
January 2025
Pius-Hospital Oldenburg, Universitätsklinik für Viszeralchirurgie, Universitätsmedizin Oldenburg, Georgstr. 12, 26121, Oldenburg, Deutschland.
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Massachusetts Alzheimer's Disease Research Center, Charlestown, MA, USA.
Background: In cerebral amyloid angiopathy, amyloid beta accumulates within the walls of blood vessels and contributes to impaired vascular integrity and function. In this work, we observe that tau protein similarly builds up along blood vessels in Alzheimer's disease brain.
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Alzheimers Dement
December 2024
University of California Irvine, Irvine, CA, USA.
Background: Alterations to spatial navigation have been suggested by previous studies to represent an early cognitive marker for those with and at risk of Alzheimer's Disease (AD). However, with most of these studies focusing on spatial memory (usage of formed spatial representations), very little is known about the extent to which spatial exploration (process by which spatial representations are formed) may be altered in AD. The aim of this study is to investigate how spatial exploration behavior may be altered in individuals with and at risk of AD, and the extent to which individuals can be classified into their clinical status based on their exploration behavior.
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View Article and Find Full Text PDFAlzheimers Dement
December 2024
Marmara University, Faculty of Sport Sciences, İstanbul, İstanbul, Turkey.
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