AI Article Synopsis
- A 40-year-old female white rhinoceros developed chronic nail-bed abscesses and, due to worsening symptoms, was switched to a nonsteroidal anti-inflammatory drug, firocoxib.
- Approximately 7 days later, the rhino exhibited skin lesions characterized by vesicles and bullae on its thorax, abdomen, and limbs, with no infectious agents found in cytology and culture tests.
- Histological analysis revealed significant skin damage similar to drug reactions observed in humans, leading to a suspicion of an adverse reaction to firocoxib.
Article Abstract
A 40 yr-old female white rhinoceros (Ceratotherium simum) suffered from chronic nail-bed abscesses. Due to worsening of clinical signs, the animal's nonsteroidal anti-inflammatory treatment was switched to firocoxib. Approximately 7 days after this change, the animal developed multifocal vesicles and bullae along the lateral aspects of the thorax and abdomen, the dorsum, and the proximal limbs. Cytology and culture did not identify an infectious etiology. Histologically, the lesions consisted of a severe, subacute vesiculobullous dermatitis with intraepidermal to subepidermal clefting with areas of individual keratinocyte necrosis and minor neutrophilic epidermal infiltrates. These findings are similar to those seen in some drug reactions in people; therefore an adverse drug reaction to the firocoxib was suspected.
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| http://dx.doi.org/10.1638/2011-0128.1 | DOI Listing |
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