AI Article Synopsis
- - The study aimed to determine if early self-diagnosis and treatment of bacterial vaginosis (BV) could help reduce preterm births among pregnant Indonesian women.
- - A total of 331 participants were divided into two groups: one received a self-evaluation kit and treatment, while the other did not; results showed no significant difference in preterm birth rates between the groups.
- - The vaginal acidity test used for self-diagnosis had low sensitivity for detecting BV, making it unreliable despite having reasonable specificity, leading to the conclusion that early self-treatment did not impact preterm birth rates.
Article Abstract
Objective: To assess whether early self-diagnosis and treatment of bacterial vaginosis (BV) could lower the preterm birth rate among a group of Indonesian women.
Methods: A randomized controlled trial of 331 pregnant women (14-18 weeks) was conducted. Participants were randomly assigned to either the active model group (n=176) or the control group (n=155). Women in the active model group were equipped with a kit to self-evaluate vaginal pH; those with a positive test result were treated with a twice daily dose of 500 mg of metronidazole for 7 days. The primary end point was preterm birth rate.
Results: There were 6 (3.8%) and 8 (5.4%) preterm births in the active model and control groups, respectively (P=0.468). No spontaneous abortions were recorded in either group. When compared with the gold standard (Gram staining), the vaginal acidity test had low ability to detect BV, with 88.7% specificity and 36.9% sensitivity. The positive predictive value of the test was 35.0% PPV, while the negative predictive value was 89.4%.
Conclusion: Early self-diagnosis and treatment of BV did not reduce the preterm birth rate of the study group. ClinicalTrial.govnumber:NCT01232192.
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| http://dx.doi.org/10.1016/j.ijgo.2012.01.007 | DOI Listing |
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