AI Article Synopsis
Article Abstract
Nitrofurylacrylic acid sodium salt is a substance of moderate toxicity. Its LD50 for male rats after oral administration comprises 1220 mg/kg, for female rats--1400 mg/kg. The minimal toxic dose, in case of long-term administration comprises 14 mg/kg. At the level of doses from 0.04 to 4.0 mg/kg no mutagenic effect was detected. Oral and subcutaneous administration of minimal tolerance doses of the agent induced formation of malignant neoplasms developing, predominantly, from the epithelial tissue, with localization depending on the route of the agent administration. A conclusion has been made on impossibility of using this substance as a food additive.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The use of topical antiseptic solutions in the healing process of post-surgical skin wounds in dogs (Canis lupus familiaris).
Acta Cir Bras
January 2025
Universidade Federal Rural de Pernambuco - Programa de Pós-Graduação em Medicina Veterinária - Departamento de Morfologia e Fisiologia Animal - Recife (PE) - Brazil.
Purpose: To evaluate whether the effectiveness of topical antiseptic solutions in restoring skin continuity solutions is related to their antimicrobial action or to their action in maintaining moisture, in dogs undergoing elective surgeries.
Methods: Forty dogs, 20 males and 20 females, underwent orchiectomy and oophorectomy, respectively. Thereafter, the animals were allocated into four groups (n = 5) and treated with different topical solutions: polyhexanide 0.
Interlaboratory comparison of particle filtration efficiency testing equipment.
J Occup Environ Hyg
January 2025
Metrology Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.
Particle filtration efficiency (PFE) is a critical property of face masks, with the most common test methods using sodium chloride as a challenge aerosol. In the absence of bottom-up uncertainty budgets for PFE, interlaboratory comparisons provide an alternative route to robustly quantify the precision and bias of the method. This work presents the results of several interlaboratory comparisons of particle filtration efficiency performed across a network of laboratories.
View Article and Find Full Text PDFNot All Antiseptic Solutions Are Equivalent in Removing Biofilm: A Comparison Across Different Orthopaedic Surfaces.
J Bone Joint Surg Am
January 2025
Adult Reconstruction and Joint Replacement, Hospital for Special Surgery, New York, NY.
Background: Antiseptic solutions are commonly utilized during total joint arthroplasty (TJA) to prevent and treat periprosthetic joint infection (PJI). The purpose of this study was to investigate which antiseptic solution is most effective against methicillin-sensitive Staphylococcus aureus (MSSA) and Escherichia coli biofilms established in vitro on orthopaedic surfaces commonly utilized in total knee arthroplasty: cobalt-chromium (CC), oxidized zirconium (OxZr), and polymethylmethacrylate (PMMA).
Methods: MSSA and E.
Sodium-Directed Crosstalk Between Immune Cells and Lymphatic Vessels.
Curr Hypertens Rep
January 2025
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Purpose Of Review: The role of the lymphatic system in clearing extravasated fluids, lipid transport, and immune surveillance is well established, and lymphatic vasculature can provide a vital role in facilitating crosstalk among various organ systems. Lymphatic vessels rely on intrinsic and local factors to absorb and propel lymph from the interstitium back to the systemic circulation. The biological implications of local influences on lymphatic vessels are underscored by the exquisite sensitivity of these vessels to environmental stimuli.
View Article and Find Full Text PDFArabidopsis glycosyltransferase UGT86A1 promotes plant adaptation to salt and drought stresses.
Physiol Plant
January 2025
The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education; Shandong Key Laboratory of Precision Molecular Crop Design and Breeding; School of Life Sciences, Shandong University, Qingdao, China.
UDP-glycosyltransferases (UGTs) are the largest glycosyltransferase family developed during the evolution of the plant kingdom. However, their physiological significance in abiotic stress adaptation in land plants is largely unknown. In this study, we identified a UGT gene from Arabidopsis thaliana, UGT86A1, that was significantly induced by salt and drought stresses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!