AI Article Synopsis
- T1AM is a new chemical messenger similar to thyroid hormone that interacts with specific receptors called TAARs, though its physiological role is still unclear.
- Researchers synthesized a radiolabeled version of T1AM and injected it into mice to study its distribution in various organs, finding significant accumulation in the gallbladder, stomach, intestine, liver, and kidney.
- Although T1AM showed systemic distribution, the expression of TAARs was minimal in most tissues, indicating that T1AM may interact with other molecular targets beyond just TAARs.
Article Abstract
3-Iodothyronamine (T1AM) is a novel chemical messenger, structurally related to thyroid hormone, able to interact with G protein-coupled receptors known as trace amine-associated receptors (TAARs). Little is known about the physiological role of T1AM. In this prospective, we synthesized [125I]-T1AM and explored its distribution in mouse after injecting in the tail vein at a physiological concentration (0.3 nM). The expression of the nine TAAR subtypes was evaluated by quantitative real-time PCR. [125I]-T1AM was taken up by each organ. A significant increase in tissue vs blood concentration occurred in gallbladder, stomach, intestine, liver, and kidney. Tissue radioactivity decreased exponentially over time, consistent with biliary and urinary excretion, and after 24 h, 75% of the residual radioactivity was detected in liver, muscle, and adipose tissue. TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8 in intestine, spleen, and testis. Thus, while T1AM has a systemic distribution, TAARs are only expressed in certain tissues suggesting that other high-affinity molecular targets besides TAARs exist.
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| http://dx.doi.org/10.1530/JOE-12-0055 | DOI Listing |
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