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Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice.
IBRO Neurosci Rep
June 2025
Department of Anesthesiology, The Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China.
Introduction: Perioperative neurocognitive dysfunction (PND) is a significant challenge for patients who need surgery worldwide. Morphine can trigger an intense inflammatory reaction in the central nervous system (CNS) at the same time as analgesia, thus adverse effects aggravating PND. Microglia polarization is closely involved in the regulation of neuroinflammation and the TLR4/MyD88/NF-κB signaling pathway.
View Article and Find Full Text PDFTreatment of posterolateral tibial plateau fractures through the articular line approach.
BMC Musculoskelet Disord
January 2025
Department of Orthopedics, Lishui Central Hospital, Zhejiang, 323000, China.
Background: Posterolateral tibial plateau fractures pose significant challenges for orthopedic surgeons due to the anatomical risks associated with the posterolateral approach. Despite numerous surgical techniques available, there lacks a consensus on the optimal approach.
Methods: Articular line incision approach was employed on 12 patients suffering from posterolateral tibial plateau fractures.
Minimally Invasive Radial-Ulnar and Tibial Fracture Management with Supracutaneous Locking Plates in Dogs and Cats.
Vet Comp Orthop Traumatol
January 2025
Department of Surgery, University of Ondokuz Mayıs, Faculty of Veterinary Medicine, Samsun, Turkey.
Objective: This study aimed to report the clinical, radiographic, and computed tomography results of supracutaneous locking plate (SLP) application in radial-ulnar and tibial fractures.
Study Design: In this clinical prospective study, cats and dogs with nonarticular radial, ulnar, and tibial fractures were managed with SLP. Surgical records, fracture healing, complications, and lameness were reviewed during scheduled rechecks.
The single antegrade sling graft: a novel hamstring autograft technique for combined anterior cruciate ligament and anterolateral ligament reconstruction.
Arch Orthop Trauma Surg
January 2025
Department of Orthopedic Surgery, Suez Canal University Hospital, Kilo 4.5 Ring Road, Ismailia, 41111, Egypt.
Introduction: As a result of increased incidence of anterior cruciate ligament (ACL) injury in young athletes, there is a rise in the indications surgical ACL reconstruction procedures. The value of anterolateral ligament (ALL) reconstruction emerges as a proposed solution to prevent graft failures and improve stability in this high demanding category of patients. The purpose of this study is to present our experience with a novel hamstring auto-grafting technique, the single antegrade sling graft (SASG), for combined reconstruction of both ACL and ALL using autologous gracilis (GR) and semitendinosus (ST) grafts utilizing a single femoral tunnel and double tibial tunnels.
View Article and Find Full Text PDFDo Percutaneously Applied Medial Proximal Tibia Plates Need To Go Beneath the Pes Tendons?
Iowa Orthop J
January 2025
Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute, Charlotte, North Carolina, USA.
Background: Bicondylar tibial plateau fractures are often associated with significant soft tissue compromise making operative treatment challenging. Dual plating through a two-incision approach following temporary external fixation has been shown to improve complication rates although deep infection rates remain high.The objective was to evaluate early outcomes following a novel technique of percutaneous application of the medial plate superficial to the pes anserinus tendons.
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