Images of two phantoms were obtained with use of an advanced multiple-beam equalization radiography system, and scatter fractions were estimated with use of a photostimulable phosphor imaging system. Scatter fractions in the equalized images were lower in the mediastinum-equivalent areas and higher in the lung-equivalent areas, relative to images that were conventionally acquired with use of an antiscatter grid. The differences are attributed to a reduction in incident exposure in the lungs and the presence of cross-scatter between lung and mediastinal regions.
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http://dx.doi.org/10.1148/radiology.177.3.2244003 | DOI Listing |
J Funct Biomater
January 2025
Institute for Bioscience and Biotechnology Research, University of Maryland Rockville, Rockville, MD 20850, USA.
Hepatitis C virus (HCV) is a major public health concern, and the development of an effective HCV vaccine plays an important role in the effort to prevent new infections. Supramolecular co-assembly and co-presentation of the HCV envelope E1E2 heterodimer complex and core protein presents an attractive vaccine design strategy for achieving effective humoral and cellular immunity. With this objective, the two antigens were non-covalently assembled with an immunostimulant (TLR 7/8 agonist) into virus-mimicking polymer nanocomplexes (VMPNs) using a biodegradable synthetic polyphosphazene delivery vehicle.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Laboratory Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Hematological parameters available on automated hematology analyzers have been shown to be useful indicators for hematological disorders. However, extensive studies especially in aplastic anemia for these indices are sparse. Our aim was to investigate the clinical utility of hematological parameters in aplastic anemia.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
Laboratoire Ondes et Milieux Complexes LOMC UMR CNRS 6294, Université Le Havre Normandie, 75 rue Bellot, Le Havre, France.
Inhomogeneous media made of random configurations of coated circular cylinders are considered. The effective properties-wave number, mass density, bulk modulus-are discussed and illustrated. The effects of the volume fraction of the scatterers and surrounding fluid are also examined.
View Article and Find Full Text PDFOsteoporos Sarcopenia
December 2024
Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Objectives: Osteoblast is known to regulate hematopoiesis according to preclinical studies but the causal relationship in human remains uncertain. We aimed to evaluate causal relationships of bone mineral density (BMD) with blood cell traits using genetic data.
Methods: Summary statistics from the largest available genome-wide association study were retrieved for total body BMD (TBBMD), lumbar spine BMD (LSBMD), femoral neck BMD (FNBMD) and 29 blood cell traits including red blood cell, white blood cell and platelet-related traits.
J Chromatogr A
January 2025
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address:
Research into nanoparticle interactions with biomolecules has become increasingly important in nanomedicine. While lipid nanoparticles (LNPs) are widely used as drug delivery systems, there remains a gap in understanding their fate in circulation, which is crucial for selecting appropriate lipids during formulation development. This study is the first to use Asymmetric Flow Field Flow Fractionation (AF4) to compare two types of LNPs: MC3-LNPs and SM-102-LNPs, and their interactions with a model protein, bovine serum albumin (BSA).
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