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Alzheimers Dement
December 2024
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Bologna, Italy.
Background: Isolated REM Sleep Behavior Disorder (iRBD) is a well-recognized prodromal state of an underlying α-synucleinopathy, occurring several years before an overt neurodegenerative disorder becomes fully manifest. iRBD has been related to poorer cognitive performance and higher frequency of mild cognitive impairment (MCI). The aim of this study was to explore in detail, with structural and functional MRI, frontal-executive dysfunction in iRBD patients and to evaluate its association with cognitive performance.
View Article and Find Full Text PDFAI-Based Evaluation of Prostate MR Imaging at a Modern Low-field 0.55 T Scanner Compared to 3 T in a Screening Cohort.
Acad Radiol
December 2024
Department of Radiology, University Hospital Basel, 4051 Basel, Basel-Stadt, Switzerland.
Purpose: To evaluate the effect of lower field strength on quantitative apparent-diffusion-coefficient (ADC) values, contrast of the T2-weighted MR images and the performance of an AI-based segmentation.
Materials And Methods: 25 screening clients (61.6 ± 7.
Global functional connectivity reorganization reflects cognitive processing speed deficits and fatigue in multiple sclerosis.
Eur J Neurol
January 2025
Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czechia.
Article Synopsis
- Cognitive impairment (CI) in multiple sclerosis (MS) is linked to changes in brain connectivity measured by fMRI, but clear biomarkers for CI are needed.
- A study compared a new index (k) based on graph theory with traditional imaging markers to assess its ability to differentiate between MS patients and healthy controls, focusing on cognitive processing speed.
- Results showed lower k values in MS patients, indicating potential as a biomarker for CI and fatigue, but further validation is required due to moderate differentiation ability.
Hippocampal hub failure is linked to long-term memory impairment in anti-NMDA-receptor encephalitis: insights from structural connectome graph theoretical network analysis.
J Neurol
September 2024
Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany.
Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is characterized by distinct structural and functional brain alterations, predominantly affecting the medial temporal lobes and the hippocampus. Structural connectome analysis with graph-based investigations of network properties allows for an in-depth characterization of global and local network changes and their relationship with clinical deficits in NMDAR encephalitis.
Methods: Structural networks from 61 NMDAR encephalitis patients in the post-acute stage (median time from acute hospital discharge: 18 months) and 61 age- and sex-matched healthy controls (HC) were analyzed using diffusion-weighted imaging (DWI)-based probabilistic anatomically constrained tractography and volumetry of a selection of subcortical and white matter brain volumes was performed.
Comparison between Intravoxel Incoherent Motion and Splenic Volumetry to Predict Hepatic Fibrosis Staging in Preoperative Patients.
Diagnostics (Basel)
October 2023
Department of Digestive Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Intravoxel incoherent motion (IVIM) and splenic volumetry (SV) for hepatic fibrosis (HF) prediction have been reported to be effective. Our purpose is to compare the HF prediction of IVIM and SV in 67 patients with pathologically staged HF. SV was divided by body surface area (BSA).
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