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Revealing and mitigating the inhibitory effect of serotonin on HRP-mediated protein labelling.
Sci Rep
December 2024
Neurobiology Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Proximity-dependent biotinylation coupled with mass spectrometry enables the characterization of subcellular proteomes. This technique has significantly advanced neuroscience by revealing sub-synaptic protein networks, such as the synaptic cleft and post-synaptic density. Profiling proteins at this detailed level is essential for understanding the molecular mechanisms of neuronal connectivity and transmission.
View Article and Find Full Text PDFIncreased caveolin 1 by human antigen R exacerbates -induced atherosclerosis by modulating oxidative stress and inflammatory responses.
Cytojournal
November 2024
Department of Cardiology, The Second People's Hospital of Lanzhou City, Lanzhou, China.
Objective: Many different types of infectious oral diseases have been identified clinically, including chronic periodontitis. is the main pathogen causing chronic periodontitis, which is closely related to atherosclerosis (AS) and can promote the expression levels of caveolin 1 (Cav-1) and induced ribonucleic acid (RNA)-binding protein human antigen R (HuR). However, the roles of Cav-1 and its relationship with HuR in -mediated AS progression remain largely unknown.
View Article and Find Full Text PDFNutritional sex-specificity on bacterial metabolites during mosquito (Aedes aegypti) development leads to adult sex-ratio distortion.
Commun Biol
December 2024
Microbiota of Insect Vectors Group, Institut Pasteur de la Guyane, Cayenne, French Guiana.
Mosquitoes rely on their microbiota for B vitamin synthesis. We previously found that Aedes aegypti third-instar larvae cleared of their microbiota were impaired in their development, notably due to a lack of folic acid (vitamin B9). In this study, we found that diet supplementation using a cocktail of seven B vitamins did not improve mosquito developmental success, but rather had a significant impact on the sex-ratio of the resulting adults, with an enrichment of female mosquitoes emerging from B vitamin-treated larvae.
View Article and Find Full Text PDFTetrahedral DNA nanostructures-assisted electrochemical assay for detecting circulating tumor DNA by combining a masking tactic with 3D-hybridization chain reactions.
Talanta
November 2024
Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security , State Administration for Market Regulation, College of Life Science, China Jiliang University, Hangzhou, 310018, China. Electronic address:
Circulating tumor DNA (ctDNA) is a remarkable noninvasive tumor marker that plays a crucial role in tumor diagnosis, prognosis and treatment. However, detecting low-abundance ctDNA from a substantial amount of nucleic acids originating from healthy cells is challenging. Herein, we proposed a tetrahedral DNA nanostructures (TDNs)-assisted electrochemical biosensor for ctDNA detection.
View Article and Find Full Text PDFThe promiscuous biotin ligase TurboID reveals the proxisome of the T3SS chaperone IpgC in .
mSphere
November 2024
Department of Chemistry and Biomolecular Sciences, Centre for Chemical and Synthetic Biology, Host-Microbe Interactions Laboratory, University of Ottawa, Ottawa, Ontario, Canada.
Promiscuous biotin ligases derived from the bacterial enzyme BirA are used to identify proteins vicinal to a bait protein, thereby defining its proxisome. Despite the popularity of this approach, surprisingly little is known about its use in prokaryotes. Here, we compared the activity of four widely used promiscuous biotin ligases in the cytoplasm of , a pathogenic subgroup of .
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