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Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard.
ACS Nano
November 2024
Department of Analytical and Material Science, BASF SE, Ludwigshafen 67056, Germany.
Article Synopsis
- * New methods were employed to assess the hazards and benefits of these perovskites, revealing that their composition affects stability under lung conditions, leading to oxidative damage and the release of metals.
- * The study identified a version of perovskite with lower nickel and added palladium as the most balanced option for safe and sustainable design, though it did not enhance traditional catalytic performance, suggesting potential need for redesign in the industry.
Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants.
Int J Mol Sci
October 2024
Department of Materials Science and Physics of Metals, Ufa University of Science and Technology, 450008 Ufa, Russia.
The general trend of increasing life expectancy will consistently drive the demand for orthopedic prostheses. In addition to the elderly, the younger population is also in urgent need of orthopedic devices, as bone fractures are a relatively common injury type; it is important to treat the patient quickly, painlessly, and eliminate further health complications. In the field of traumatology and orthopedics, metals and their alloys are currently the most commonly used materials.
View Article and Find Full Text PDFPromoting ClO Generation from the HOCl + HOCl Reaction on Aqueous/Frozen Air-Water Interfaces.
J Am Chem Soc
November 2024
Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China.
Hypochlorous acid (HOCl) is considered a temporary reservoir of dichlorine monoxide (ClO). Previous studies have suggested that ClO is difficult to generate from the reaction of HOCl + HOCl in the gas phase. Here, we demonstrate that ClO can be generated from the HOCl + HOCl reaction at aqueous/frozen air-water interfaces, which is confirmed by ab initio molecular dynamic calculations.
View Article and Find Full Text PDFAn albumin unfolding and refolding cycle induced by a time-controlled pH jump.
Org Biomol Chem
December 2024
Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Article Synopsis
- The study explores how controlling the unfolding and refolding of proteins can impact their functions, with potential applications in areas like drug release and protein-based devices.
- It demonstrates a method using albumin, a common protein, where the addition of nitroacetic acid induces a controlled change in the protein's structure by altering pH levels through a chemical reaction.
- The results show that this process is reversible and that the protein can fully return to its original structure, highlighting a novel way to manipulate protein behaviors in a time-efficient manner.
Indole N-Linked Hydroperoxyl Adduct of Protein-Derived Cofactor Modulating Catalase-Peroxidase Functions.
Angew Chem Int Ed Engl
December 2024
Department of Chemistry, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.
Bifunctional catalase-peroxidase (KatG) features a posttranslational methionine-tyrosine-tryptophan (MYW) crosslinked cofactor crucial for its catalase function, enabling pathogens to neutralize hydrogen peroxide during infection. We discovered the presence of indole nitrogen-linked hydroperoxyl adduct (MYW-OOH) in Mycobacterium tuberculosis KatG in the solution state under ambient conditions, suggesting its natural occurrence. By isolating predominantly MYW-OOH-containing KatG protein, we investigated the chemical stability and functional impact of MYW-OOH.
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