AI Article Synopsis
- The study assessed the effectiveness and safety of involved-field intensity-modulated radiotherapy (IF-IMRT) in treating early-stage Hodgkin's lymphoma (HL) with mediastinal involvement among 52 patients.
- Most patients had Stage II disease, and all received chemotherapy followed by IF-IMRT, with radiation doses between 30-40 Gy.
- Results showed excellent radiation dose coverage, high survival rates (100% overall survival), and very low instances of serious toxicity, highlighting IF-IMRT as a promising treatment option for this condition.
Article Abstract
Purpose: To evaluate the dosimetric and clinical outcomes of involved-field intensity-modulated radiotherapy (IF-IMRT) for patients with early-stage Hodgkin's lymphoma (HL) with mediastinal involvement.
Methods And Materials: Fifty-two patients with early-stage HL that involved the mediastinum were reviewed. Eight patients had Stage I disease, and 44 patients had Stage II disease. Twenty-three patients (44%) presented with a bulky mediastinum, whereas 42 patients (81%) had involvement of both the mediastinum and either cervical or axillary nodes. All patients received combination chemotherapy followed by IF-IMRT. The prescribed radiation dose was 30-40 Gy. The dose-volume histograms of the target volume and critical normal structures were evaluated.
Results: The median mean dose to the primary involved regions (planning target volume, PTV1) and boost area (PTV2) was 37.5 Gy and 42.1 Gy, respectively. Only 0.4% and 1.3% of the PTV1 and 0.1% and 0.5% of the PTV2 received less than 90% and 95% of the prescribed dose, indicating excellent PTV coverage. The median mean lung dose and V20 to the lungs were 13.8 Gy and 25.9%, respectively. The 3-year overall survival, local control, and progression-free survival rates were 100%, 97.9%, and 96%, respectively. No Grade 4 or 5 acute or late toxicities were reported.
Conclusions: Despite the large target volume, IF-IMRT gave excellent dose coverage and a favorable prognosis, with mild toxicity in patients with early-stage mediastinal HL.
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| http://dx.doi.org/10.1016/j.ijrobp.2011.11.008 | DOI Listing |
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