AI Article Synopsis
- The study assessed the effectiveness of a new magnetic resonance imaging technique called intermolecular multiple quantum coherence (iMQC) for detecting single cells.
- Researchers compared images of macrophage cells using iMQC and conventional gradient echo (GE) methods, finding that iMQC provided clearer and higher-contrast images.
- The findings suggest that iMQC could be a better option than traditional MR imaging for detecting and tracking labeled single cells, especially in specific conditions.
Article Abstract
To evaluate the efficiency and feasibility of intermolecular multiple quantum coherence (iMQC) magnetic resonance (MR) imaging for single cell detection, we obtained intermolecular double quantum coherence (iDQC) and conventional gradient echo (GE) images of macrophage cells labeled by contrast agents in gel. The iDQC images obtained with echo-planar readout visualized the labeled cells effectively and with a higher contrast than seen in conventional GE images, especially at low planar resolutions and with thick slices. This implies that iDQC imaging with contrast agents could be a good alternative to conventional MR imaging for detecting labeled single cells or cell tracking under favorable conditions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794080 | PMC |
| http://dx.doi.org/10.1016/j.jmr.2012.02.014 | DOI Listing |
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