Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum.

Fitoterapia

Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China.

Published: June 2012

Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1-3) were obtained during our ongoing investigation of an ethanol extract from the stem bark of Morus wittiorum. Their structures were elucidated on the basis of spectroscopic data. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC(50) value of 1.45μM.

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http://dx.doi.org/10.1016/j.fitote.2012.03.001DOI Listing

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