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Progress and prospects for stem cell engineering. | LitMetric

Progress and prospects for stem cell engineering.

Annu Rev Chem Biomol Eng

Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.

Published: May 2012

AI Article Synopsis

  • - Stem cells have unique abilities to self-renew and differentiate into various adult cell types, making them valuable for biomedical applications.
  • - Researchers are using advanced technologies and theoretical approaches to study the environmental signals and cellular communications that influence stem cell behavior and decision-making.
  • - With the growing understanding of stem cell regulation, scientists aim to create methods that reliably control stem cell destiny for producing effective and affordable stem cell therapies for clinical use.

Article Abstract

Stem cells offer tremendous biomedical potential owing to their abilities to self-renew and differentiate into cell types of multiple adult tissues. Researchers and engineers have increasingly developed novel discovery technologies, theoretical approaches, and cell culture systems to investigate microenvironmental cues and cellular signaling events that control stem cell fate. Many of these technologies facilitate high-throughput investigation of microenvironmental signals and the intracellular signaling networks and machinery processing those signals into cell fate decisions. As our aggregate empirical knowledge of stem cell regulation grows, theoretical modeling with systems and computational biology methods has and will continue to be important for developing our ability to analyze and extract important conceptual features of stem cell regulation from complex data. Based on this body of knowledge, stem cell engineers will continue to develop technologies that predictably control stem cell fate with the ultimate goal of being able to accurately and economically scale up these systems for clinical-grade production of stem cell therapeutics.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991629PMC
http://dx.doi.org/10.1146/annurev-chembioeng-061010-114105DOI Listing

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