Objective: We retrospectively assessed the age- and sex-specific incidence and relative risk of Parkinson disease (PD) in Taiwan's diabetic population.
Research Design And Methods: Study cohort included 603,416 diabetic patients and 472,188 nondiabetic control subjects. Incidence rate and relative risk of PD (ICD-9-CM 332.0) were evaluated.
Results: The incidence of PD was 3.59 and 2.15 per 10,000 person-years for the diabetic and control group, respectively, representing a covariate adjusted hazard ratio (HR) of 1.61 (95% CI 1.56-1.66), which was substantially reduced to 1.37 (1.32-1.41) after adjusting for medical visits. Diabetes was associated with a significantly elevated risk of PD in all sex and age stratifications except in young women, with the highest HR noted for young men aged 21-40 years (2.10 [1.01-4.42]), followed by women aged 41-60 (2.05 [1.82-2.30]) and >60 years (1.65 [1.58-1.73]).
Conclusions: Diabetes is associated with an increased risk of PD onset in a Chinese population, and the relation is stronger in women and younger patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329814 | PMC |
| http://dx.doi.org/10.2337/dc11-1511 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Randomized Clinical Study Investigating the Stain Removal Efficacy of Two Experimental Dentifrices.
J Esthet Restor Dent
January 2025
All Sum Research Center Ltd., Mississauga, Ontario, Canada.
Objective: This study aims to evaluate extrinsic tooth stain removal and whitening efficacy of two experimental dentifrices containing (i) 5% sodium tripolyphosphate (STP)/1% micronized alumina or (ii) 5% STP/1% micronized alumina with abrasive silica (ED2) compared to a regular fluoride dentifrice (RFD) following 8 weeks of use.
Materials And Methods: This was a single-center, randomized, controlled, blind, three-arm, stratified, parallel-group study. Eligible participants underwent clinical assessment of stain on the facial/lingual surfaces of maxillary and mandibular teeth using the modified Lobene stain index (MLSI), and shade of the facial surfaces of the central and lateral maxillary incisors using the VITA Bleachedguide 3D-Master (VITA) shade guide.
Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs.
Neurobiol Dis
January 2025
Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA; McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA. Electronic address:
Parkinson's Disease (PD) is a multisystem disorder in which dysregulated neuroimmune crosstalk and inflammatory relay via the gut-blood-brain axis have been implicated in PD pathogenesis. Although alterations in circulating inflammatory cytokines and reactive oxygen species (ROS) have been associated with PD, no biomarkers have been identified that predict clinical progression or disease outcome. Gastrointestinal (GI) dysfunction, which involves perturbation of the underlying immune system, is an early and often-overlooked symptom that affects up to 80 % of individuals living with PD.
View Article and Find Full Text PDFStep Width Haptic Feedback for Gait Stability in Spinocerebellar Ataxia: Preliminary Results.
Mov Disord
January 2025
Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Background: Wider step width and lower step-to-step variability are linked to improved gait stability and reduced fall risk. It is unclear if patients with spinocerebellar ataxia (SCA) can learn to adjust these aspects of gait to reduce fall risk.
Objectives: The aims were to examine the possibility of using wearable step width haptic biofeedback to enhance gait stability and reduce fall risk in individuals with SCA.
Incorporating the Malnutrition Screening Tool and the Malnutrition Universal Screening Tool in Rehabilitation Practice: Comparison With the Nutrition Risk Screening 2002.
Food Sci Nutr
January 2025
Gülhane School of Medicine, Department of Physical Medicine and Rehabilitation University of Health Sciences Turkey Ankara Turkey.
To demonstrate the prevalence of malnutrition risk in a specific rehabilitation setting. The secondary aim of the study was to compare Malnutrition Screening Tool (MST) and Malnutrition Universal Screening Tool (MUST) with Nutritional Risk Screening-2002 (NRS-2002). Patients diagnosed with stroke, anoxic brain injury, spinal cord injury, multiple sclerosis, arthritis, neuromuscular diseases, Parkinson's disease, and lymphedema who were admitted to a rehabilitation hospital were included.
View Article and Find Full Text PDFRecently, a novel African ancestry specific Parkinson's disease (PD) risk signal was identified at the gene encoding glucocerebrosidase ( ). This variant (rs3115534-G) is carried by ∼50% of West African PD cases and imparts a dose-dependent increase in risk for disease. The risk variant has varied frequencies across African ancestry groups, but is almost absent in European and Asian ancestry populations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!