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Slit skin smear versus anti-phenolic glycolipid-I serology in diagnosis of leprosy: a cross sectional study.
Arch Dermatol Res
December 2024
Department of Dermatology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Leprosy is a chronic infectious disease which mainly affects the skin, nasal mucosa, and peripheral nerves. The aim of this study was to compare between the efficacies of serum anti-phenolic glycolipid 1 (APGL-I) level versus slit skin smear (SSS) in diagnosis of leprosy. This study involved 58 leprosy cases who were clinically examined, slit-skin smears were taken from all at diagnosis from four sites and APGL-I levels were seroassayed using ELISA.
View Article and Find Full Text PDFPhoton counting CT versus energy-integrating CT: A comparative evaluation of advances in image resolution, noise, and dose efficiency.
Med Phys
December 2024
Siemens Healthineers AG, Forchheim, Germany.
Background: Photon counting computed tomography (PCCT) employs direct and spectrally resolved counting of individual x-ray quanta, enhancing image quality compared to the standard energy-integrating CT (EICT).
Purpose: To evaluate the quantitative improvements in CT image quality metrics by comparing the first medical PCCT with a state-of-the-art EICT.
Methods: The PCCT versus EICT noise improvement ratio R was derived from the quantum statistics of the measurement process and measured across the clinical x-ray flux range for both systems.
Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet (12 SQ-HDM) in children with allergic rhinitis/rhinoconjunctivitis with or without asthma (MT-12): a randomised, double-blind, placebo-controlled, phase III trial.
Lancet Reg Health Eur
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
Article Synopsis
- The study focuses on the effectiveness of a sublingual immunotherapy (SLIT) tablet for treating house dust mite-induced allergic rhinitis in children aged 5-11 years, addressing a gap in existing data for this age group.
- Conducted as a Phase III randomized trial, 1460 children were divided into two groups: one receiving the SLIT tablet and the other receiving a placebo, with significant improvements observed in allergy symptoms and quality of life for the SLIT group.
- Results showed a notable 22% reduction in the total combined rhinitis score for the SLIT group compared to placebo, alongside improved scores in other related outcome measures, suggesting SLIT's potential as an effective
Comparative Analytical Study of Intravitreal Triamcinolone Acetonide Versus Bevacizumab in Managing Diabetic Macular Edema: Insights From a Tertiary Eye Care Facility in India.
Cureus
November 2024
Ophthalmology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, IND.
Aim: This study aims to compare the effects of intravitreal triamcinolone acetonide (IVTA) and bevacizumab (IVB) in diabetic macular edema (DME) management.
Methodology: A prospective interventional study was conducted at a tertiary eye care hospital in Tamil Nadu, India. The study received approval from the institutional ethics committee, and informed consent was obtained from all participants.
Umbilical Cord Blood-Derived Products in Autoimmune Systemic Syndromes with Severe Dryness: A Pilot Study.
Medicina (Kaunas)
October 2024
Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Article Synopsis
- Human umbilical cord blood serum (HUCBS) shows promise as an effective treatment for severe ocular surface disorders (OSDs) by speeding up healing and reducing inflammation, benefiting patients who haven't found relief through standard therapies.
- A study of 49 patients with various severe OSDs was conducted at San Marco Hospital in Italy, categorizing patients based on causes like rheumatologic diseases and graft-versus-host disease.
- Results indicated significant improvement in multiple assessments, including patient-reported outcomes and clinical evaluations, demonstrating the potential of HUCBS in treating resistant cases of OSDs.
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