Direct carboxamidation of indoles by palladium-catalyzed C-H activation and isocyanide insertion.

Chem Commun (Camb)

State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530, China.

Published: April 2012

A selective C3 carboxamidation of indoles including free (N-H) ones by palladium-catalyzed sequential C-H activation-isocyanide insertion has been developed.

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Source
http://dx.doi.org/10.1039/c2cc30351eDOI Listing

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