AI Article Synopsis
- A computerized morphometric model was developed to assess and quantify the morphological characteristics of large regenerative nodules (LRN), high-grade dysplastic nodules (HGDN), and hepatocellular carcinoma (HCC) in livers affected by HCV and cirrhosis.
- The analysis involved staining tissue samples with various methods, revealing that features like volume fraction, hepatocyte nuclei count, and nuclear/cytoplasmic ratios effectively distinguished between the different types of nodules.
- The study found significant differences in the volume fractions of blood vessel structures and reticulin surface fractions among the groups, suggesting the model could enhance histological evaluations in cirrhotic liver conditions.
Article Abstract
We generated a computerized morphometric model to evaluate and quantify the morphological features in large regenerative nodules (LRN), high-grade dysplastic nodules (HGDN) and hepatocellular carcinoma (HCC). Sixteen LRN, 10 HGDN and 16 HCC in HCV-cirrhotic livers were stained with H&E, smooth muscle actin, CD34, CD31 and reticulin to evaluate volume and surface fractions. On H&E stains, the most discriminatory features between LRN, HGDN and HCC were volume fraction and the number of hepatocyte nuclei in unit volume and hepatocyte nuclear/cytoplasmic ratio. On immunohistochemistry, volume fractions of capillarised sinusoids, capillary units and isolated arteries were significantly different among all groups and highest in HCC; surface fraction of reticulin was markedly decreased in HCC. Our morphometric model is an objective method for quantification of the morphological changes of the nodular lesions, and it could be applied to studies involving histological evaluation of the spectrum of nodular lesions arising in the cirrhotic liver.
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| http://dx.doi.org/10.1016/j.prp.2012.02.007 | DOI Listing |
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