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Chemical composition, antimicrobial, antiradical and anticholinesterase activity of the essential oil of Pulicaria stephanocarpa from Soqotra. | LitMetric
Pharmacognosy Department, Faculty of Pharmacy, Sana'a University, P. O. Box 13150, Sana'a, Yemen.
Published: January 2012
AI Article Synopsis
The study focused on the essential oil extracted from Pulicaria stephanocarpa leaves, analyzing its composition and bioactivities using GC-MS.
The oil contained 83 identified compounds, with (E)-Caryophyllene being the most abundant at 13.4%, along with several other notable compounds.
The oil exhibited effective antimicrobial activity against Gram-positive bacteria and Candida albicans, demonstrated significant antioxidant capabilities with a DPPH IC50 of 330 microg/mL, and showed a 47% inhibition of acetylcholinesterase (AChE) at a concentration of 200 microg/mL.
Article Abstract
The chemical composition of the hydrodistilled leaf essential oil from Pulicaria stephanocarpa Balf. Fil was determined by GC-MS analysis, and its antimicrobial, antioxidant and anticholinesterase (AChE) activities were evaluated. Eighty-three compounds were identified representing 97.2% of the total oil. (E)-Caryophyllene 13.4%, (E)-nerolidol 8.5%, caryophyllene oxide 8.5%, alpha-cadinol 8.2% spathulenol 6.8% and tau-cadinol 4.7%, were the main components. Antimicrobial activity of the oil, evaluated using the disc diffusion and broth dilution methods, demonstrated the highest susceptibility on Gram-positive bacteria and Candida albicans. The free radical scavenging ability of the oil was assessed by the DPPH assay to show antiradical activity with IC50 of 330 microg/mL. Moreover, the oil revealed an AChE inhibitory activity of 47% at a concentration of 200 microg/mL using Ellman's method.
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