AI Article Synopsis
- The study aimed to evaluate how glaucoma affects the optical attenuation coefficient of the retinal nerve fiber layer (RNFL) using Spectral Domain Optical Coherence Tomography (SD-OCT) images.
- Researchers analyzed OCT images from 10 healthy eyes and 30 glaucomatous eyes at various severity levels, measuring RNFL reflectivity and its relationship to visual function.
- Results showed that the RNFL's attenuation coefficient significantly decreased with increased glaucoma severity, particularly in specific locations around the optic nerve head, indicating its potential as a new method for assessing glaucoma.
Article Abstract
Purpose: To demonstrate the effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer (RNFL) in Spectral Domain Optical Coherence Tomography (SD-OCT) images.
Methods: We analyzed images of the peripapillary areas in 10 healthy and 30 glaucomatous eyes (mild, moderate, and advanced glaucoma, 10 eyes each), scanned with the Spectralis OCT (Heidelberg Engineering GmbH, Dossenheim, Germany). To calculate the RNFL attenuation coefficient (μ(att)), determined by the scattering properties of the RNFL, we used a model that normalized the reflectivity of the RNFL by the retinal pigment epithelium. The analysis was performed at four preset locations at 1.3 and 1.7 mm from the center of the optic nerve head (ONH) (i.e., temporally, superiorly, nasally, and inferiorly) and on averages per eye. To assess the structure-function relationship, we correlated the μ(att) to the mean deviation (MD) in standard automated perimetry.
Results: The μ(att) of the RNFL decreased up to 40% with increasing disease severity, on average as well as in each location around the ONH (Jonckheere-Terpstra test, P < 0.019 in all tests). The μ(att) of the RNFL depended significantly on the location around the ONH in all eyes (Kruskal-Wallis test, P < 0.014) and was lowest nasally from the ONH. The μ(att) correlated significantly with the MD in SAP (R(2) = 0.337).
Conclusions: The measurements clearly demonstrated that the μ(att) of the RNFL decreased with increasing disease severity. The RNFL attenuation coefficient may serve as a new method to quantify glaucoma in SD-OCT images.
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| http://dx.doi.org/10.1167/iovs.11-8436 | DOI Listing |
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